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dc.contributor.authorUeland, Thor
dc.contributor.authorLaugsand, Lars Erik
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorJanszky, Imre
dc.contributor.authorPlatou, Carl Geoffrey Parrinder
dc.contributor.authorMichelsen, Annika
dc.contributor.authorDamås, Jan Kristian
dc.contributor.authorAukrust, Pål
dc.contributor.authorÅsvold, Bjørn Olav
dc.date.accessioned2018-08-22T12:52:54Z
dc.date.available2018-08-22T12:52:54Z
dc.date.issued2017-06-06
dc.description.abstract<p><i>Background</i>: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals.</p> <p><i>Methods</i>: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11.3 years, 1587 incident MI cases were registered, and compared to 3959 age- and sex-matched controls.</p> <p><i>Results</i>: Higher serum sCD163 (Q4 vs. Q1 OR: 1.27, P-trend 0.002), sCD14 (Q4 vs. Q1 OR: 1.38, P-trend < 0.001), and especially sCD25 (Q4 vs. Q1 OR: 1.45, P-trend < 0.001), were associated with increased MI risk in the age-and sex adjusted models. However, after additional adjustment for cardiovascular risk factors these associations were strongly attenuated (Q4 vs Q1 ORs between 1.02 and 1.12, P-trends between 0.30 and 0.58).</p> <p><i>Conclusions</i>: sCD163, sCD14 and sCD25 may reflect leukocyte activation and inflammatory mechanisms related to atherogenesis, but do not predict MI risk above and beyond conventional cardiovascular risk factors.en_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.ijcard.2017.05.106> https://doi.org/10.1016/j.ijcard.2017.05.106</a>. Accepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationUeland, T., Laugsand, L.E., Vatten, L.J., Janszky, I., Platou, C.G.P., Michelsen, A., ... Åsvold, B.O. (2017). Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study. International Journal of Cardiology, 243, 502-504. https://doi.org/10.1016/j.ijcard.2017.05.106en_US
dc.identifier.cristinIDFRIDAID 1498291
dc.identifier.doi10.1016/j.ijcard.2017.05.106
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.urihttps://hdl.handle.net/10037/13543
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalInternational Journal of Cardiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/SFF/223255/Norway/Centre of Molecular Inflammation Research/CEMIR/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectLeukocyte markersen_US
dc.subjectMyocardial infarctionen_US
dc.titleMonocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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