Show simple item record

dc.contributor.authorHolvik, Kristin
dc.contributor.authorAhmed, Luai Awad
dc.contributor.authorForsmo, Siri
dc.contributor.authorGjesdal, Clara Gram
dc.contributor.authorGrimnes, Guri
dc.contributor.authorSamuelsen, Sven Ove
dc.contributor.authorSchei, Berit
dc.contributor.authorBlomhoff, Rune
dc.contributor.authorTell, Grethe S
dc.contributor.authorMeyer, Haakon E
dc.date.accessioned2018-08-24T13:19:53Z
dc.date.available2018-08-24T13:19:53Z
dc.date.issued2013-08-01
dc.description.abstract<p><i>Background</i>: Despite considerable interest, the relationship between circulating 25-hydroxyvitamin D and the risk of hip fracture is not fully established.</p> <p><i>Objective</i>: The objective of the study was to study the association between serum 25-hydroxyvitamin D concentrations [s-25(OH)D] and the risk of hip fracture in Norway, a high-latitude country that has some of the highest hip fracture rates worldwide.</p> <p><i>Methods</i>: A total of 21 774 men and women aged 65–79 years attended 4 community-based health studies during 1994–2001. Information on subsequent hip fractures was retrieved from electronic hospital discharge registers, with a maximum follow-up of 10.7 years. Using a stratified case-cohort design, s-25(OH)D was determined by HPLC-atmospheric pressure chemical ionization-mass spectrometry in stored serum samples in hip fracture cases (n = 1175; 307 men, 868 women) and in gender-stratified random samples (n = 1438). Cox proportional hazards regression adapted for the case-cohort design was performed.</p> <p><i>Results</i>: We observed an inverse association between s-25(OH)D and hip fracture; those with s-25(OH)D in the lowest quartile (<42.2 nmol/L) had a 38% [95% confidence interval (CI) 9–74%] increased risk of hip fracture compared with the highest quartile (≥67.9 nmol/L) in a model accounting for age, gender, study center, and body mass index. The association was stronger in men than in women: hazard ratio 1.65 (95% CI 1.04–2.61) vs hazard ratio 1.25 (95% CI 0.95–1.65).</p> <p><i>Conclusion</i>: In this prospective case-cohort study of hip fractures, the largest ever reported, we found an increased risk of hip fracture in subjects in the lowest compared with the highest quartile of serum 25-hydroxyvitamin D. In accordance with the findings of previous community-based studies, low vitamin D status was a modest risk factor for hip fracture.en_US
dc.description.sponsorshipCentral Norway Regional Health Authorityen_US
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in <i>Journal of Clinical Endocrinology and Metabolism</i> following peer review. The version of record Holvik, K., Ahmed, L.A., Forsmo, S., Gjesdal, C.G., Grimnes, G., Samuelsen, S.O., ... Meyer, H.E. (2013). Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study. Journal of Clinical Endocrinology and Metabolism, 98(8), 3341-3350. https://doi.org/10.1210/jc.2013-1468 is available online at: <a href=https://doi.org/10.1210/jc.2013-1468> https://doi.org/10.1210/jc.2013-1468</a>.en_US
dc.identifier.citationHolvik, K., Ahmed, L.A., Forsmo, S., Gjesdal, C.G., Grimnes, G., Samuelsen, S.O., ... Meyer, H.E. (2013). Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study. Journal of Clinical Endocrinology and Metabolism, 98(8), 3341-3350. https://doi.org/10.1210/jc.2013-1468en_US
dc.identifier.cristinIDFRIDAID 1049206
dc.identifier.doi10.1210/jc.2013-1468
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.urihttps://hdl.handle.net/10037/13596
dc.language.isoengen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.journalJournal of Clinical Endocrinology and Metabolism
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/191257/Norway/Hip fractures: Predictors, incidence and survival. NOREPOS: The Norwegian Epidemiological Osteoporosis Studies//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Midical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801en_US
dc.titleLow Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record