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dc.contributor.authorHeiberg, Ina Heidi
dc.contributor.authorJacobsen, Bjarne K.
dc.contributor.authorNesvåg, Ragnar
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorNæss, Øyvind
dc.contributor.authorYstrøm, Eivind
dc.contributor.authorHultman, Christina M
dc.contributor.authorHøye, Anne
dc.date.accessioned2018-09-07T08:23:50Z
dc.date.available2018-09-07T08:23:50Z
dc.date.issued2018-08-23
dc.description.abstractIndividuals with schizophrenia or substance use disorder have a substantially increased mortality compared to the general population. Despite a high and probably increasing prevalence of comorbid substance use disorder in people with schizophrenia, the mortality in the comorbid group has been less studied and with contrasting results. We performed a nationwide open cohort study from 2009 to 2015, including all Norwegians aged 20–79 with schizophrenia and/or substance use disorder registered in any specialized health care setting in Norway, a total of 125,744 individuals. There were 12,318 deaths in the cohort, and total, sex-, age- and cause-specific standardized mortality ratios (SMRs) were calculated, comparing the number of deaths in patients with schizophrenia, schizophrenia only, substance use disorder only or a co-occurring diagnosis of schizophrenia and substance use disorder to the number expected if the patients had the age-, sex- and calendar-year specific death rates of the general population. The SMRs were 4.9 (95% CI 4.7–5.1) for all schizophrenia patients, 4.4 (95% CI 4.2–4.6) in patients with schizophrenia without substance use disorder, 6.6 (95% CI 6.5–6.8) in patients with substance use disorder only, and 7.4 (95% CI 7.0–8.2) in patients with both schizophrenia and substance use disorder. The SMRs were elevated in both genders, in all age groups and for all considered causes of death, and most so in the youngest. Approximately 27% of the excess mortality in all patients with schizophrenia was due to the raised mortality in the subgroup with comorbid SUD. The increased mortality in patients with schizophrenia and/or substance use disorder corresponded to more than 10,000 premature deaths, which constituted 84% of all deaths in the cohort. The persistent mortality gap highlights the importance of securing systematic screening and proper access to somatic health care, and a more effective prevention of premature death from external causes in this group.en_US
dc.description.sponsorshipThe Regional Health Authorities in Northern Norwayen_US
dc.descriptionThis is the peer reviewed version of the following article:Heiberg, I.H., Jacobsen, B.K., Nesvåg, R., Bramness, J.G., Reichborn-Kjennerud, T., Næss, Ø., ... Høye, A. (2018). Total and cause-specific standardized mortality ratios in patients with schizophrenia and/or substance use disorder. <i>PLoS ONE</i>, 13(8). https://doi.org/10.1371/journal.pone.0202028. Source at <a href=https://doi.org/10.1371/journal.pone.0202028> https://doi.org/10.1371/journal.pone.0202028</a>.en_US
dc.identifier.citationHeiberg, I.H., Jacobsen, B.K., Nesvåg, R., Bramness, J.G., Reichborn-Kjennerud, T., Næss, Ø., ... Høye, A. (2018). Total and cause-specific standardized mortality ratios in patients with schizophrenia and/or substance use disorder. PLoS ONE, 13(8). https://doi.org/10.1371/journal.pone.0202028en_US
dc.identifier.cristinIDFRIDAID 1607338
dc.identifier.doi10.1371/journal. pone.0202028
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/13704
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofHeiberg, I.H. (2019). Mortality, substance use disorder and cardiovascular health care in persons with severe mental illness. (Doctoral thesis). <a href=https://hdl.handle.net/10037/16284>https://hdl.handle.net/10037/16284</a>.
dc.relation.journalPLoS ONE
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0202028&type=printable
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.titleTotal and cause-specific standardized mortality ratios in patients with schizophrenia and/or substance use disorderen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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