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dc.contributor.authorNimptsch, Katharina
dc.contributor.authorSong, Mingyang
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorKatsoulis, Michail
dc.contributor.authorFreisling, Heinz
dc.contributor.authorJenab, Mazda
dc.contributor.authorGunter, Marc J.
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorChong, Dawn Q.
dc.contributor.authorJensen, Majken K.
dc.contributor.authorWu, Chunsen
dc.contributor.authorOvervad, Kim
dc.contributor.authorKühn, Tilman
dc.contributor.authorBarrdahl, Myrto
dc.contributor.authorMelander, Olle
dc.contributor.authorJirström, Karin
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorSieri, Sabina
dc.contributor.authorPanico, Salvatore
dc.contributor.authorCross, Amanda J.
dc.contributor.authorRiboli, Elio
dc.contributor.authorvan Guelpen, Bethany
dc.contributor.authorMyte, Robin
dc.contributor.authorHuerta, José María
dc.contributor.authorRodriguez-Barranco, Miguel
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorTravis, Ruth
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorCarbonnel, Franck
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBonet, Catalina
dc.contributor.authorPalli, Domenico
dc.contributor.authorJanke, Jürgen
dc.contributor.authorLee, Young-Ae
dc.contributor.authorBoeing, Heiner
dc.contributor.authorGiovannucci, Edward L.
dc.contributor.authorOgino, Shuji
dc.contributor.authorFuchs, Charles S.
dc.contributor.authorRimm, Eric
dc.contributor.authorWu, Kana
dc.contributor.authorChan, Andrew T.
dc.contributor.authorPischon, Tobias
dc.date.accessioned2018-09-11T12:00:38Z
dc.date.available2018-09-11T12:00:38Z
dc.date.issued2017-05-26
dc.description.abstractHigher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses’ Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the <i>ADIPOQ</i> gene. We created an <i>ADIPOQ</i> allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The <i>ADIPOQ</i> allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the <i>ADIPOQ</i> allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.en_US
dc.description.sponsorshipEuropean Commission (DG-SANCO) The International Agency for Research on Cancer World Cancer Research Fund International Wereld Kanker Onderzoek Fonds U.S. NIH grantsen_US
dc.descriptionThis is a pre-print of an article published in <i>European Journal of Epidemiology</i>. The final authenticated version is available online at: <a href=https://doi.org/10.1007/s10654-017-0262-y> https://doi.org/10.1007/s10654-017-0262-y</a>.en_US
dc.identifier.citationNimptsch, K., Song, M., Aleksandrova, K., Katsoulis, M., Freisling, H., Jenab, M., ... Pischon, T. (2017). Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies. European Journal of Epidemiology, 32(5), 419-430. https://doi.org/10.1007/s10654-017-0262-yen_US
dc.identifier.cristinIDFRIDAID 1489384
dc.identifier.doi10.1007/s10654-017-0262-y
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.urihttps://hdl.handle.net/10037/13752
dc.language.isoengen_US
dc.publisherSpringer Verlag (Germany)en_US
dc.relation.journalEuropean Journal of Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectAdiponectinen_US
dc.subjectADIPOQen_US
dc.subjectColorectal canceren_US
dc.subjectMendelian Randomizationen_US
dc.titleGenetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studiesen_US
dc.typeJournal articleen_US
dc.typeManuskriptno
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US
dc.typePreprinten_US


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