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dc.contributor.authorBorgund Barnung, Runa
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorUlven, Stine Marie
dc.contributor.authorSkeie, Guri
dc.contributor.authorOlsen, Karina Standahl
dc.date.accessioned2018-10-24T07:27:31Z
dc.date.available2018-10-24T07:27:31Z
dc.date.issued2018-08-09
dc.description.abstractNorwegians are the second highest consumers of coffee in the world. Lately, several studies have suggested that beneficial health effects are associated with coffee consumption. By analyzing whole-blood derived, microarray based mRNA gene expression data from 958 cancer-free women from the Norwegian Women and Cancer Post-Genome Cohort, we assessed the potential associations between coffee consumption and gene expression profiles and elucidated functional interpretation. Of the 958 women included, 132 were considered low coffee consumers (<1 cup of coffee/day), 422 moderate coffee consumers (1–3 cups of coffee/day), and 404 were high coffee consumers (>3 cups of coffee/day). At a false discovery rate <0.05, 139 genes were differentially expressed between high and low consumers of coffee. A subgroup of 298 nonsmoking, low tea consumers was established to isolate the effects of coffee from smoking and potential caffeine containing tea consumption. In this subgroup, 297 genes were found to be differentially expressed between high and low coffee consumers. Results indicate differentially expressed genes between high and low consumers of coffee with functional interpretations pointing towards a possible influence on metabolic pathways and inflammation.en_US
dc.descriptionSource at <a href=https://doi.org/10.3390/nu10081047> https://doi.org/10.3390/nu10081047</a>.en_US
dc.identifier.citationBorgund Barnung, R., Nøst, T.H., Ulven, S.M., Skeie, G. & Olsen, K.S. (2018). Coffee Consumption and Whole-Blood Gene Expression in the Norwegian Women and Cancer Post-Genome Cohort. Nutrients, 10(8). https://doi.org/10.3390/nu10081047en_US
dc.identifier.cristinIDFRIDAID 1600718
dc.identifier.doi10.3390/nu10081047
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/10037/14024
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalNutrients
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectwhole-blooden_US
dc.subjectmRNAen_US
dc.subjectTranscriptomicsen_US
dc.subjectgene expressionen_US
dc.subjectcoffeeen_US
dc.subjectthe Norwegian Women and Cancer Cohort (NOWAC)en_US
dc.titleCoffee Consumption and Whole-Blood Gene Expression in the Norwegian Women and Cancer Post-Genome Cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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