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dc.contributor.authorSkjefstad, Kaja Konstanse
dc.contributor.authorJohannessen, Charles
dc.contributor.authorGrindstad, Thea K.W.
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorPaulsen, Erna Elise
dc.contributor.authorPedersen, Mona Irene
dc.contributor.authorDønnem, Tom
dc.contributor.authorAndersen, Sigve
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorRichardsen, Elin
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorBusund, Lill-Tove
dc.date.accessioned2018-10-24T08:29:11Z
dc.date.available2018-10-24T08:29:11Z
dc.date.issued2018-06-04
dc.description.abstractMicro RNAs (miRNA) are small non-coding RNAs that post-transcriptionally regulate gene expression. Dysregulation of miRNA cluster 143/145 has been reported in several malignancies, but their role in non-small cell lung cancer (NSCLC) remains elusive. This study investigates the prognostic impact of miR-143 and miR-145 in primary tumors and metastatic lymph nodes in NSCLC tissue. Tissue from 553 primary tumors and 143 matched metastatic lymph nodes were collected and tissue microarrays were constructed. In situ hybridization was used to evaluate miR-143 and miR-145 expression in tumor epithelial cells and stromal cells in the primary tumors and lymph nodes. In vivo data was supplemented with functional studies of cell lines in vitro to evaluate the role of miR-143 and miR-145 in NSCLC tumorigenesis. In our cohort, stromal miR-143 (S-miR-143) and miR-145 (S-miR-145) expression in primary tumor tissue were independent prognosticators of improved disease-specific survival (DSS) in female (S-miR-143, HR: 0.53, p = 0.019) and male patients (S-miR-145, HR: 0.58, p = 0.021), respectively. Interesting correlations between the miR cluster 143/145 and previously investigated steroid hormone receptors from the same cohort were identified, substantiating their gender dependent significance.en_US
dc.description.sponsorshipNorthern Norway Health Region Authority The Norwegian Cancer Societyen_US
dc.descriptionCopyright Nature Research. Source at <a href=https://doi.org/10.1038/s41598-018-26864-w> https://doi.org/10.1038/s41598-018-26864-w</a>.en_US
dc.identifier.citationSkjefstad, K., Johannessen, C., Grindstad, T., Kilvær, T.K., Paulsen, E.-E., Pedersen, M.I., ... Busund, L.-T. (2018). A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer. <i>Scientific Reports</i>, 8(8549). https://doi.org/10.1038/s41598-018-26864-wen_US
dc.identifier.cristinIDFRIDAID 1592542
dc.identifier.doi10.1038/s41598-018-26864-w
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/14025
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.ispartofJohannessen, C.W. (2019). Expression and functional properties of selected miRNAs in human cancer tissue and cancer cell lines. (Doctoral thesis). <a href=https://hdl.handle.net/10037/15195>https://hdl.handle.net/10037/15195. </a>
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleA gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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