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dc.contributor.authorLekva, Tove
dc.contributor.authorGodang, Kristin
dc.contributor.authorMichelsen, Annika E.
dc.contributor.authorQvigstad, Elisabeth
dc.contributor.authorNormann, Kjersti R.
dc.contributor.authorNorwitz, Errol R.
dc.contributor.authorTore, Henriksen
dc.contributor.authorBollerslev, Jens
dc.contributor.authorRoland, Marie
dc.contributor.authorUeland, Thor
dc.date.accessioned2018-10-30T13:10:37Z
dc.date.available2018-10-30T13:10:37Z
dc.date.issued2018-09-06
dc.description.abstractEarly detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14-16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study using different diagnostic criteria (WHO1999, IADPSG2010, WHO2013, NORWAY2017) and (2) develop pre-diabetes 5 years postpartum focusing on first trimester β-cell function in a separate study of 300 women from the STORK cohort. The sensitivity of the 14-16 week OGTT to identify women who would develop GDM or have LGA babies was low, and we could not identify alternative cut-offs to exclude women not at risk or identify women that could benefit from early intervention. First trimester β-cell function was a stronger determinant than third trimester β-cell function of predicting maternal pre-diabetes. In conclusion, in our normal low-risk population, the 75 g OGTT at 14-16 weeks is insufficient to identify candidates for early treatment of GDM or identify women not likely to develop GDM or have LGA babies. First trimester β-cell function may predict pre-diabetes 5 years postpartum.en_US
dc.descriptionSource at <a href=http://dx.doi.org/10.1038/s41598-018-31614-z>http://dx.doi.org/10.1038/s41598-018-31614-z</a>en_US
dc.identifier.citationLekva, T., Godang, K., Michelsen, A. E., Qvigstad, E., Normann, K. R., Norwitz, E. R., Aukrust, P., Henriksen, T., Bollerslev, J., Roland, M., … Ueland, T. (2018). Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14-16 Weeks' Gestation. Scientific reports, 8(1), 13392. http://dx.doi.org/10.1038/s41598-018-31614-zen_US
dc.identifier.cristinIDFRIDAID 1616090
dc.identifier.doi10.1038/s41598-018-31614-z
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/14062
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en_US
dc.titlePrediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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