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dc.contributor.authorBall, Jocasta
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorMorseth, Bente
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorNjølstad, Inger
dc.contributor.authorTiwari, Sweta
dc.contributor.authorSharashova, Ekaterina
dc.date.accessioned2018-11-07T13:56:39Z
dc.date.available2018-11-07T13:56:39Z
dc.date.issued2018-04-19
dc.description.abstract<p><i>Background</i>: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated.</p> <p><i>Methods and Results</i>: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications.</p> <p>Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m2 compared with 23 kg/m2 were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk.</p> <p><i>Conclusions</i>: Within a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women.</p>en_US
dc.description.sponsorshipThe Norwegian Health Association in Troms County. National Health and Medical Research Council of Australia National Heart Foundation of Australia The Victorian Governmenten_US
dc.descriptionSource at <a href=https://doi.org/10.1161/JAHA.117.008414> https://doi.org/10.1161/JAHA.117.008414</a>.en_US
dc.identifier.citationBall, J., Løchen, M.-L., Wilsgaard, T., Schirmer, H., Hopstock, L.A., Morseth, B., ... Sharashova, E. (2018). Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study. <i>Journal of the American Heart Association</i>, 7(9). <a href=https://doi.org/10.1161/JAHA.117.008414> https://doi.org/10.1161/JAHA.117.008414</a>en_US
dc.identifier.cristinIDFRIDAID 1581769
dc.identifier.doi10.1161/JAHA.117.008414
dc.identifier.issn2047-9980
dc.identifier.urihttps://hdl.handle.net/10037/14116
dc.language.isoengen_US
dc.publisherWiley Open Accessen_US
dc.relation.journalJournal of the American Heart Association
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectincidenceen_US
dc.subjectatrial fibrillationen_US
dc.subjectsex differencesen_US
dc.subjectbody mass indexen_US
dc.titleSex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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