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dc.contributor.authorJohansen, Steinar D.
dc.contributor.authorMjelle, Kenneth A.
dc.contributor.authorKarlsen, Bård O.
dc.contributor.authorJørgensen, Tor Erik
dc.contributor.authorMoum, Truls
dc.date.accessioned2008-05-26T10:18:02Z
dc.date.available2008-05-26T10:18:02Z
dc.date.issued2008-01-11
dc.description.abstractBackground: Halibuts are commercially important flatfish species confined to the North Pacific and North Atlantic Oceans. We have determined the complete mitochondrial genome sequences of four specimens each of Atlantic halibut (Hippoglossus hippoglossus), Pacific halibut (Hippoglossus stenolepis) and Greenland halibut (Reinhardtius hippoglossoides), and assessed the nucleotide variability within and between species. Results: About 100 variable positions were identified within the four specimens in each halibut species, with the control regions as the most variable parts of the genomes (10 times that of the mitochondrial ribosomal DNA). Due to tandem repeat arrays, the control regions have unusually large sizes compared to most vertebrate mtDNAs. The arrays are highly heteroplasmic in size and consist mainly of different variants of a 61-bp motif. Halibut mitochondrial genomes lacking arrays were also detected. Conclusion: The complexity, distribution, and biological role of the heteroplasmic tandem repeat arrays in halibut mitochondrial control regions are discussed. We conclude that the most plausible explanation for array maintenance includes both the slipped-strand mispairing and DNA recombination mechanisms.en
dc.format.extent480284 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationBMC Genomics 9(2008) article no 10en
dc.identifier.doidoi:10.1186/1471-2164-9-10
dc.identifier.issn1471-2164
dc.identifier.urihttps://hdl.handle.net/10037/1425
dc.identifier.urnURN:NBN:no-uit_munin_1202
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en
dc.titleHalibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombinationen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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