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dc.contributor.authorOrrem, Hilde Lang
dc.contributor.authorShetelig, Christian
dc.contributor.authorUeland, Thor
dc.contributor.authorLimalanathan, Shanmuganathan
dc.contributor.authorNilsson, Per
dc.contributor.authorHusebye, Trygve Guttorm
dc.contributor.authorAukrust, Pål
dc.contributor.authorSeljeflot, Ingebjørg
dc.contributor.authorHoffmann, Pavel
dc.contributor.authorEritsland, Jan
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorAndersen, Geir Øystein
dc.contributor.authorYndestad, Arne
dc.date.accessioned2019-01-08T14:31:13Z
dc.date.available2019-01-08T14:31:13Z
dc.date.issued2018-05-28
dc.description.abstract<p><i>Background</i>: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling.</p> <p><i>Methods</i>: Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n = 65).</p> <p><i>Results</i>: IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates.</p> <p><i>Conclusion</i>: Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI.</p>en_US
dc.description.sponsorshipHelse Sør-Øst Regional Health Authority European Community's Seventh Framework Programme The Norwegian Council The Odd Fellow Foundation The Simon Fougner Hartmann Family Funden_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.ijcard.2018.05.032> https://doi.org/10.1016/j.ijcard.2018.05.032</a>. Licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationOrrem, H.L., Shetelig, C., Ueland, T., Limalanathan, S., Nilsson, P.H., Husebye, T., ... Yndestad, A. (2018). Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction. <i>International Journal of Cardiology</i>, 268, 187-192. https://doi.org/10.1016/j.ijcard.2018.05.032en_US
dc.identifier.cristinIDFRIDAID 1592948
dc.identifier.doi10.1016/j.ijcard.2018.05.032
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.urihttps://hdl.handle.net/10037/14395
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalInternational Journal of Cardiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/240099/Norway/Metaflammation in cardiovascular disease//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectInflammationen_US
dc.subjectCytokineen_US
dc.subjectInterleukin-1en_US
dc.subjectAcute coronary syndromesen_US
dc.subjectMyocardial infarctionen_US
dc.subjectVentricular remodellingen_US
dc.titleSoluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarctionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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