dc.contributor.author | Toraskar, Jimita Prashant | |
dc.contributor.author | Magnussen, Synnøve | |
dc.contributor.author | Chawla, Konika | |
dc.contributor.author | Svineng, Gunbjørg | |
dc.contributor.author | Steigedal, Tonje S. | |
dc.date.accessioned | 2019-01-11T10:44:38Z | |
dc.date.available | 2019-01-11T10:44:38Z | |
dc.date.issued | 2018-10-30 | |
dc.description.abstract | Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin‐dependent manner. Here, we used reverse‐phase protein array (RPPA) to analyze NPNT‐triggered intracellular signaling in the 66cl4 mouse breast cancer cell line. The results showed that the integrin‐binding enhancer motif is important for the cellular effects upon NPNT interaction with its receptors, including phosphorylation of p38 mitogen‐activated protein kinase (MAPK). Furthermore, analysis using prediction tools suggests involvement of NPNT in promoting cell viability. In conclusion, our results indicate that NPNT, via its integrin‐binding motifs, promotes cell viability through phosphorylation of p38 MAPK. | en_US |
dc.description.sponsorship | Central Norway Regional Health Authority
North Norwegian Regional Health Authorities
The Erna and Olav Aakre Foundation for Cancer Research
The Blix Family Fund for Medical Research
UiT—The Arctic University of Norway | en_US |
dc.description | Source at <a href=https://doi.org/10.1002/2211-5463.12544> https://doi.org/10.1002/2211-5463.12544</a>. | en_US |
dc.identifier.citation | Toraskar, J., Magnussen, S.N., Chawla, K., Svineng, G. & Steigedal, T.S. (2018). Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif. <i>FEBS Open Bio</i>. https://doi.org/10.1002/2211-5463.12544 | en_US |
dc.identifier.cristinID | FRIDAID 1627492 | |
dc.identifier.doi | 10.1002/2211-5463.12544 | |
dc.identifier.issn | 2211-5463 | |
dc.identifier.uri | https://hdl.handle.net/10037/14423 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | FEBS Open Bio | |
dc.rights.accessRights | openAccess | en_US |
dc.subject | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711 | en_US |
dc.subject | breast cancer | en_US |
dc.subject | cell viability | en_US |
dc.subject | extracellular matrix | en_US |
dc.subject | integrin nephronectin | en_US |
dc.subject | p38 MAPK | en_US |
dc.title | Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |