Show simple item record

dc.contributor.authorSeternes, Ole Morten
dc.contributor.authorKidger, Andrew M
dc.contributor.authorKeyse, Stephen M
dc.date.accessioned2019-01-15T12:17:51Z
dc.date.available2019-01-15T12:17:51Z
dc.date.issued2018-09-08
dc.description.abstractIt is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions between MAP kinase pathways and other key signalling modules. As our knowledge of the regulation, substrate specificity and catalytic mechanisms of MKPs has matured, more recent work using genetic models has revealed key physiological functions for MKPs and also uncovered potentially important roles in regulating the pathophysiological outcome of signalling with relevance to human diseases. These include cancer, diabetes, inflammatory and neurodegenerative disorders. It is hoped that this understanding will reveal novel therapeutic targets and biomarkers for disease, thus contributing to more effective diagnosis and treatment for these debilitating and often fatal conditions.en_US
dc.description.sponsorshipCancer Research UK Program Grant The MRC The Norwegian Cancer Society Northern Norway Regional Health Authority/Helse Nord RHF The Aakre foundationen_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.bbamcr.2018.09.002> https://doi.org/10.1016/j.bbamcr.2018.09.002</a>.en_US
dc.identifier.citationSeternes, O.-M., Kidger, A.M. & Keyse, S.M. (2018). Dual-specificity MAP kinase phosphatases in health and disease. <i>Biochimica et Biophysica Acta (BBA) - Molecular Cell Research</i>, 1866(1), 124-143. https://doi.org/10.1016/j.bbamcr.2018.09.002en_US
dc.identifier.cristinIDFRIDAID 1625372
dc.identifier.doi10.1016/j.bbamcr.2018.09.002
dc.identifier.issn0167-4889
dc.identifier.issn1879-2596
dc.identifier.urihttps://hdl.handle.net/10037/14448
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBBA - Molecular Cell Research
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en_US
dc.subjectMAP kinaseen_US
dc.subjectMAP kinase phosphataseen_US
dc.subjectdiabetesen_US
dc.subjectObesityen_US
dc.subjectNeuropathologyen_US
dc.subjectOncogenic signallingen_US
dc.titleDual-specificity MAP kinase phosphatases in health and diseaseen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record