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dc.contributor.authorJareid, Mie
dc.contributor.authorThalabard, Jean-Christophe
dc.contributor.authorAarflot, Morten
dc.contributor.authorBøvelstad, Hege Marie
dc.contributor.authorLund, Eiliv
dc.contributor.authorBraaten, Tonje
dc.date.accessioned2019-01-16T08:32:01Z
dc.date.available2019-01-16T08:32:01Z
dc.date.issued2018-03-02
dc.description.abstract<p><i>Objective</i>: Women with ovarian cancer have poor survival rates, which have proven difficult to improve; therefore primary prevention is important. The levonorgestrel-releasing intrauterine system (LNG-IUS) prevents endometrial cancer, and recent studies suggested that it may also prevent ovarian cancer, but with a concurrent increased risk of breast cancer. We compared adjusted risks of ovarian, endometrial, and breast cancer in ever users and never users of LNG-IUS.</p> <p><i>Methods</i>: Our study cohort consisted of 104,318 women from the Norwegian Women and Cancer Study, 9144 of whom were ever users and 95,174 of whom were never users of LNG-IUS. Exposure information was taken from self-administered questionnaires, and cancer cases were identified through linkage to the Cancer Registry of Norway. Relative risks (RRs) with 95% confidence intervals (CIs) were estimated with Poisson regression using robust error estimates.</p> <p><i>Results</i>: Median age at inclusion was 52 years and mean follow-up time was 12.5 (standard deviation 3.7) years, for a total of 1,305,435 person-years. Among ever users of LNG-IUS there were 18 cases of epithelial ovarian cancer, 15 cases of endometrial cancer, and 297 cases of breast cancer. When ever users were compared to never users of LNG-IUS, the multivariable RR of ovarian, endometrial, and breast cancer was 0.53 (95% CI: 0.32, 0.88), 0.22 (0.13, 0.40), and 1.03 (0.91, 1.17), respectively.</p> <p><i>Conclusion</i>: In this population-based prospective cohort study, ever users of LNG-IUS had a strongly reduced risk of ovarian and endometrial cancer compared to never users, with no increased risk of breast cancer.en_US
dc.description.sponsorshipUiT The Arctic University of Norway, Tromsø, Norway Paris Descartes Universityen_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> Published version available at <a href=https://doi.org/10.1016/j.ygyno.2018.02.006> https://doi.org/10.1016/j.ygyno.2018.02.006</a>.en_US
dc.identifier.citationJareid, M., Thalabard, J.-C., Aarflot, M., Bøvelstad, H., Lund, E. & Braaten, T. (2018). Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Study. <i>Gynecologic Oncology</i>, 149(1), 127-132. https://doi.org/10.1016/j.ygyno.2018.02.006en_US
dc.identifier.cristinIDFRIDAID 1581312
dc.identifier.doi10.1016/j.ygyno.2018.02.006
dc.identifier.issn0090-8258
dc.identifier.issn1095-6859
dc.identifier.urihttps://hdl.handle.net/10037/14454
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofJareid, M. (2022). Epithelial ovarian cancer. Population-based cohort studies. The NOWAC Study and Postgenome biobank. (Doctoral thesis). <a href=https://hdl.handle.net/10037/26790>https://hdl.handle.net/10037/26790</a>
dc.relation.journalGynecologic Oncology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectVDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803en_US
dc.subjectBrystkreft / Breast Canceren_US
dc.subjectEggstokkreft / Ovarian canceren_US
dc.subjectLevonorgestrel / Levonorgestrelen_US
dc.subjectLivmorkreft / Cervical canceren_US
dc.titleLevonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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