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dc.contributor.authorGavrilyuk, Oxana
dc.contributor.authorBraaten, Tonje
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorLicaj, Idlir
dc.contributor.authorLund, Eiliv
dc.date.accessioned2019-02-08T07:16:38Z
dc.date.available2019-02-08T07:16:38Z
dc.date.issued2018-05-21
dc.description.abstract<p><i>Introduction</i>: Lifetime number of years of menstruation (LNYM) reflects a woman's cumulative exposure to endogenous estrogen and can be used as a measure of the combined effect of reproductive factors related to endometrial cancer (EC) risk.</p> <p><i>Material and methods</i>: We aimed to study the association between LNYM and EC risk among postmenopausal women and calculate the population attributable fraction of EC for different LNYM categories. Our study sample consisted of 117 589 women from the Norwegian Women and Cancer (NOWAC) Study. All women were aged 30‐70 years at enrollment and completed a baseline questionnaire between 1991 and 2006. Women were followed up for EC to December 2014 through linkages to national registries. We used Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (95% CIs), adjusted for potential confounders.</p> <p><i>Results</i>: In all, 720 women developed EC. We found a statistically significant, positive dose‐response relationship between LNYM and EC, with a 9.1% higher risk for each additional year of LNYM (P for trend < .001). Using the LNYM category ≥40 as a reference, the hazard ratios for LNYM <25, 25‐29, 30‐34, 35‐39 were 0.17 (95% CI 0.22‐0.27), 0.25 (95% CI 0.17‐0.36), 0.43 (95% CI 0.32‐0.58), and 0.68 (95% CI 0.51‐0.92), respectively. The association between LNYM and EC was independent of incomplete pregnancies, menopausal hormone therapy, diabetes, and body mass index. When considering the population attributable fraction, 67% of EC was estimated to be attributable to LNYM ≥25 years.</p> <p><i>Conclusions</i>: Our study supports that increasing LNYM is an important and independent predictor of EC risk.</p>en_US
dc.description.sponsorshipNorthern Norway Regional Health Authority Faculty of Health Sciences UiT The Arctic University of Norway Norwegian Cancer Societyen_US
dc.descriptionSource at <a href=https://doi.org/10.1111/aogs.13381> https://doi.org/10.1111/aogs.13381</a>.en_US
dc.identifier.citationGavrilyuk, O., Braaten, T., Weiderpass, E., Licaj, I. & Lund, E. (2018). Lifetime number of years of menstruation as a risk index for postmenopausal endometrial cancer in the Norwegian Women and Cancer Study. <i>Acta Obstetricia et Gynecologica Scandinavica, 97</i>(10), 1168-1177. https://doi.org/10.1111/aogs.13381en_US
dc.identifier.cristinIDFRIDAID 1608249
dc.identifier.doi10.1111/aogs.13381
dc.identifier.issn0001-6349
dc.identifier.issn1600-0412
dc.identifier.urihttps://hdl.handle.net/10037/14649
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalActa Obstetricia et Gynecologica Scandinavica
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectendometrial canceren_US
dc.subjectmenopauseen_US
dc.subjectnumber of menstruationsen_US
dc.subjectprospective studyen_US
dc.subjectreproductive factorsen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en_US
dc.titleLifetime number of years of menstruation as a risk index for postmenopausal endometrial cancer in the Norwegian Women and Cancer Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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