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dc.contributor.authorWard, Heather A
dc.contributor.authorWhitman, Julia
dc.contributor.authorMuller, David C
dc.contributor.authorJohansson, Mattias
dc.contributor.authorJakszyn, Paula
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorPalli, Domenico
dc.contributor.authorFanidi, Anouar
dc.contributor.authorVermeulen, Roel
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHansen, Louise
dc.contributor.authorDahm, Christina C.
dc.contributor.authorOvervad, Kim
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorAffret, Aurélie
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renee
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorBerrino, Franco
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorPeeters, Petra H
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorAgudo, Antonio
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorHuerta, Jose Maria
dc.contributor.authorArdanaz, Eva
dc.contributor.authorDrake, Isabel
dc.contributor.authorBrunnström, Hans
dc.contributor.authorJohansson, Mikael
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorFreisling, Heinz
dc.contributor.authorStepien, Magdalena
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorRiboli, Elio
dc.contributor.authorCross, Amanda J.
dc.date.accessioned2019-02-26T11:16:32Z
dc.date.available2019-02-26T11:16:32Z
dc.date.issued2018-10-18
dc.description.abstract<p><i>Background</i>: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding.</p> <p><i>Methods</i>: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available.</p> <p><i>Results</i>: Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00–1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02–1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case–control subset.</p> <p><i>Conclusions</i>: Greater haem iron intake may be modestly associated with lung cancer risk.en_US
dc.description.sponsorshipThe European Commission The International Agency for Research on Cancer Danish Cancer Society Ligue Contre le Cancer Institut Gustave Roussy Mutuelle Générale de l’Education Nationale Institut National de la Santé et de la Recherche Médicale (INSERM) German Cancer Aid German Cancer Research Centre (DKFZ) Federal Ministry of Education and Research (BMBF) Deutsche Krebshilfe Deutsches Krebsforschungszentrum Federal Ministry of Education and Research The Hellenic Health Foundation Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy National Research Council Dutch Ministry of Public Health, Welfare and Sports Netherlands Cancer Registry LK Research Funds Dutch Prevention Funds Dutch ZON (Zorg Onderzoek Nederland) World Cancer Research Fund (WCRF) Statistics Netherlands (The Netherlands) ERC-2009-AdG 232997 Nordforsk Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway) Health Research Fund (FIS) PI13/00061 to Granada PI13/01162 to EPIC-Murcia Regional Governments of Andalucía, Asturias, Basque Country, Murcia Swedish Cancer Society Swedish Research Council County Councils of Skåne and Västerbotten Cancer Research UK Medical Research Councilen_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1038/s41430-018-0271-2> https://doi.org/10.1038/s41430-018-0271-2</a>.en_US
dc.identifier.citationWard, H.A., Whitman, J., Muller, D.C., Johansson, M., Jakszyn, P., Weiderpass, E., ... Cross, A.J. (2018). Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. <i>European Journal of Clinical Nutrition</i>. https://doi.org/10.1038/s41430-018-0271-2en_US
dc.identifier.cristinIDFRIDAID 1647757
dc.identifier.doi10.1038/s41430-018-0271-2
dc.identifier.issn0954-3007
dc.identifier.issn1476-5640
dc.identifier.urihttps://hdl.handle.net/10037/14773
dc.language.isoengen_US
dc.relation.journalEuropean Journal of Clinical Nutrition
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/Final Report Summary - TICE (TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY)/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleHaem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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