Show simple item record

dc.contributor.authorLofterød, Trygve
dc.contributor.authorMortensen, Elin Synnøve
dc.contributor.authorNalwoga, Hawa
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorFrydenberg, Hanne
dc.contributor.authorRisberg, Terje
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorMcTiernan, Anne
dc.contributor.authorAziz, Sura Mohammed
dc.contributor.authorWist, Erik
dc.contributor.authorStensvold, Andreas
dc.contributor.authorReitan, Jon Brinchmann
dc.contributor.authorAkslen, Lars A.
dc.contributor.authorThune, Inger
dc.date.accessioned2019-03-04T10:32:38Z
dc.date.available2019-03-04T10:32:38Z
dc.date.issued2018-06-15
dc.description.abstract<i>Background</i>: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.<p> <p><i>Methods</i>: A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Pre-diagnostic triglycerides, total-cholesterol and HDL-cholesterol were measured, and detailed clinical and histopathological data were obtained. Using tissue microarray, all breast cancer cases were reclassified into the following subtypes: Luminal A, Luminal B, HER2-enriched, and triple negative breast cancer (TNBC). Multivariable Cox proportional hazards regression models were used to study the associations between pre-diagnostic lipids and breast cancer recurrence, mortality, and survival.<p> <p><i>Results</i>: A total of 464 breast cancer patients, with mean age at diagnosis of 57.9 years, were followed for a mean 8.4 years. TNBC patients in the highest tertile of triglycerides (≥ 1.23 mmol/l) had 3 times higher overall mortality compared to TNBC patients in the lowest tertile (≤ 0.82 mmol/l) (HR 2.99, 95% CI 1.17–7.63), and the 5-year overall survival was 19% lower for TNBC patients in the highest vs. lowest tertile of triglycerides (65% vs. 84%). TNBC patients in the highest tertile of the HDL-cholesterol/total-cholesterol ratio (≥0.35), compared to those in the lowest tertile (≤0.27), had a 67% reduced overall mortality risk (HR 0.33, 95% CI 0.12–0.89). No associations were observed between lipids and prognostic outcome among breast cancer patients overall, or among patients with luminal A and luminal B subtypes. Among HER2-enriched patients, pre-diagnostic triglyceride level was inversely associated with overall mortality.<p> <p><i>Conclusion</i>: Our study suggests that pre-diagnostic triglycerides and the HDL-cholesterol/total-cholesterol ratio may independently provide unique information regarding prognostic outcome among triple negative breast cancer patients. However, a small sample size underlines the need for additional studies.<p>en_US
dc.description.sponsorshipThe Norwegian ExtraFoundation for Health and Rehabilitation Norwegian Cancer Societyen_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12885-018-4568-2>https://doi.org/10.1186/s12885-018-4568-2. </a> © The Author(s). 2018en_US
dc.identifier.citationLofterød, T., Mortensen, E., Nalwoga, H., Wilsgaard, T., Frydenberg, H., Risberg, T. ... Thune, I. (2018). Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes. <i>BMC Cancer</i>, 18:654. https://doi.org/10.1186/s12885-018-4568-2en_US
dc.identifier.cristinIDFRIDAID 1592321
dc.identifier.doi10.1186/s12885-018-4568-2
dc.identifier.issn1471-2407
dc.identifier.urihttps://hdl.handle.net/10037/14814
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectBreast canceren_US
dc.subjectLipidsen_US
dc.subjectMolecular subtypeen_US
dc.subjectTriple negative breast canceren_US
dc.subjectSurvivalen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleImpact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypesen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record