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dc.contributor.authorRypdal, Martin wibe
dc.contributor.authorRypdal, Veronika Gjertsen
dc.contributor.authorBurney, Jennifer A.
dc.contributor.authorCayan, Daniel
dc.contributor.authorBainto, Emelia
dc.contributor.authorSkochko, Shannon
dc.contributor.authorTremoulet, Adriana H.
dc.contributor.authorCreamean, Jessie
dc.contributor.authorShimizu, Chisato
dc.contributor.authorKim, Ji-Hoon
dc.contributor.authorBurns, Jane C.
dc.date.accessioned2019-03-05T08:59:26Z
dc.date.available2019-03-05T08:59:26Z
dc.date.issued2018-11-12
dc.description.abstractKawasaki Disease (KD) is the most common cause of pediatric acquired heart disease, but its etiology remains unknown. We examined 1164 cases of KD treated at a regional children’s hospital in San Diego over a period of 15 years and uncovered novel structure to disease incidence. KD cases showed a well-defined seasonal variability, but also clustered temporally at much shorter time scales (days to weeks), and spatiotemporally on time scales of up to 10 days and spatial scales of 10–100 km. Temporal clusters of KD cases were associated with strongly significant regional-scale air temperature anomalies and consistent larger-scale atmospheric circulation patterns. Gene expression analysis further revealed a natural partitioning of KD patients into distinct groups based on their gene expression pattern, and that the different groups were associated with certain clinical characteristics that also exhibit temporal autocorrelation. Our data suggest that one or more environmental triggers exist, and that episodic exposures are modulated at least in part by regional weather conditions. We propose that characterization of the environmental factors that trigger KD in genetically susceptible children should focus on aerosols inhaled by patients who share common disease characteristics.en_US
dc.descriptionSource at <a href=https://doi.org/10.1038/s41598-018-33124-4> https://doi.org/10.1038/s41598-018-33124-4</a>.en_US
dc.identifier.citationRypdal, M.W., Rypdal, V.G., Burney, J.A., Cayan, D., Bainto, E., Skochko, S., ... Burns, J.C. (2018). Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers. <i>Scientific Reports, 8</i>, 16140. https://doi.org/10.1038/s41598-018-33124-4en_US
dc.identifier.cristinIDFRIDAID 1647978
dc.identifier.doi10.1038/s41598-018-33124-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/14828
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.titleClustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggersen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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