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dc.contributor.authorKovalenko, Anton Alexandrovich
dc.contributor.authorAnda, Erik Eik
dc.contributor.authorOdland, Jon Øyvind
dc.contributor.authorNieboer, Evert
dc.contributor.authorBrenn, Tormod
dc.contributor.authorKrettek, Alexandra
dc.date.accessioned2019-03-05T11:40:49Z
dc.date.available2019-03-05T11:40:49Z
dc.date.issued2018-06-24
dc.description.abstractCardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88].en_US
dc.descriptionSource at: <a href=http://doi.org/10.3390/ijerph15071320> http://doi.org/10.3390/ijerph15071320 </a>en_US
dc.identifier.citationKovalenko, A. A., Anda, E. E, Odland, J. Ø., Nieboer, E., Brenn, T., Krettek, A. (2018). Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study. <i>International Journal of Environmental Research and Public Health, 15</i>(7), 1-11. http://doi.org/10.3390/ijerph15071320en_US
dc.identifier.cristinIDFRIDAID 1606825
dc.identifier.doi10.3390/ijerph15071320
dc.identifier.issn1660-4601
dc.identifier.urihttps://hdl.handle.net/10037/14847
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Environmental Research and Public Health
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.titleRisk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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