Show simple item record

dc.contributor.authorRønning, Leif
dc.contributor.authorBakkehaug, Jens P.
dc.contributor.authorRødland, Lars
dc.contributor.authorKildal, Anders B.
dc.contributor.authorMyrmel, Truls
dc.contributor.authorHow, Ole-Jakob
dc.date.accessioned2019-03-06T11:14:33Z
dc.date.available2019-03-06T11:14:33Z
dc.date.issued2018-10-11
dc.description.abstractAcute ischemic cardiogenic shock is associated with poor prognosis, and the impact of inotropic support on diastolic function in this context is unclear. We assessed two suggested new inotropic strategies in a clinically relevant pig model of ischemic acute heart failure (AHF): treatment with the myosin activator omecamtiv mecarbil (OM) or dobutamine and ivabradine (D+I). Left ventricular (LV) ischemia was induced in anesthetized pigs by coronary microembolization (n = 12). The animals then received OM (bolus 0.75 mg/kg, followed by 0.5 mg/kg per h) (n = 6) or D+I (5 μg/kg per min + 0.29 ± 0.16 mg/kg) (n = 6), respectively. Ischemia reduced the stroke volume (SV), despite the increased left atrial pressure associated with impaired LV early relaxation, systolic dilatation, and LV late diastolic stiffness. Both treatments improved systolic ejection, but only D+I increased the SV from 26 ± 5 to 33 ± 5 mL. D+I enhanced LV early relaxation (Tau; from 45 ± 11 to 29 ± 4 msec) and prolonged the diastolic time (DT) from 338 ± 60 to 352 ± 40 msec. In contrast, OM prolonged Tau (42 ± 5 to 62 ± 10 msec) and shortened the DT (from 326 ± 68 to 248 ± 84 msec). Our data suggest that enhanced early relaxation by D+I improves LV pump function in postischemic acute heart failure. In contrast, OM worsened lusitropy in this model.en_US
dc.descriptionSource at <a href= https://doi.org/10.14814/phy2.13879> https://doi.org/10.14814/phy2.13879 </a>.en_US
dc.identifier.citationRønning, L., Bakkehaug, J. P., Rødland, L., Kildal, A. B., Myrmel, T., & How, O.-J. (2018). Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure. Physiological Reports, 6(19), e13879. https://doi.org/10.14814/phy2.13879.en_US
dc.identifier.cristinIDFRIDAID 1630636
dc.identifier.doi10.14814/phy2.13879
dc.identifier.issn2051-817X
dc.identifier.urihttps://hdl.handle.net/10037/14864
dc.language.isoengen_US
dc.publisherWiley Open Acessen_US
dc.relation.journalPhysiological Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Clinical pharmacology: 739en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Klinisk farmakologi: 739en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Human and veterinary science physiology: 718en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Human og veterinærmedisinsk fysiologi: 718en_US
dc.subjectAcute heart failureen_US
dc.subjectCardiogenic shocken_US
dc.subjectContractilityen_US
dc.subjectDiastolic functionen_US
dc.subjectInotropic agentsen_US
dc.titleOpposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failureen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record