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dc.contributor.authorWendelbo, Øystein
dc.contributor.authorOpheim, Elin Netland
dc.contributor.authorHervig, Tor
dc.contributor.authorLunde, Turid Helen Felli
dc.contributor.authorBruserud, Øystein
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorReikvam, Håkon
dc.date.accessioned2019-03-12T12:45:13Z
dc.date.available2019-03-12T12:45:13Z
dc.date.issued2018-08-29
dc.description.abstract<p><i>Background and Objectives</i>: In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases.</p> <p><i>Materials and Methods</i>: Twenty‐seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post‐transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model.</p> <p><i>Results</i>: Febrile patients had significantly lower corrected Hb increment, significantly increased values of IL‐6, IL‐8, IL‐10 and G‐CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results demonstrated an association between haemoglobin increment, fever and inflammatory mediators. Febrile patients had a significantly lower corrected Hb increment compared to nonfebrile patients, when adjusting for mediators. When fever was kept constant, a significant negative association between haemoglobin increment and the proinflammatory mediators IL‐6 and IL‐8 was observed.</p> <p><i>Conclusion</i>: Both fever and the inflammatory mediators IL‐6 and IL‐8 were negatively associated with post‐transfusion haemoglobin increment.</p>en_US
dc.descriptionThis is the pre-peer reviewed version of the following article: Wendelbo, Ø., Opheim, E.N., Hervig, T., Lunde, T.H.F., Bruserud, Ø., Mollnes, T.E. & Reikvam, H. (2018). Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases. <i>Vox Sanguinis, 113</i>, 657-668, which has been published in final form at <a href=https://doi.org/10.1111/vox.12703> https://doi.org/10.1111/vox.12703</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationWendelbo, Ø., Opheim, E.N., Hervig, T., Lunde, T.H.F., Bruserud, Ø., Mollnes, T.E. & Reikvam, H. (2018). Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases. <i>Vox Sanguinis, 113</i>, 657-668. https://doi.org/10.1111/vox.12703en_US
dc.identifier.cristinIDFRIDAID 1612421
dc.identifier.doi10.1111/vox.12703
dc.identifier.issn0042-9007
dc.identifier.issn1423-0410
dc.identifier.urihttps://hdl.handle.net/10037/14951
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalVox Sanguinis
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/SFF/223255/Norway/Centre of Molecular Inflammation Research/CEMIR/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.subjectfeveren_US
dc.subjectred‐blood‐cell concentratesen_US
dc.subjecttransfusionen_US
dc.titleCytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseasesen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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