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dc.contributor.authorToft, Helge Prytz
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorLien, Lars
dc.contributor.authorAbebe, Dawit Shawel
dc.contributor.authorWampold, Bruce E.
dc.contributor.authorTilden, Terje
dc.contributor.authorHestad, Knut
dc.contributor.authorNeupane, Sudan Prasad
dc.date.accessioned2019-03-14T13:03:24Z
dc.date.available2019-03-14T13:03:24Z
dc.date.issued2018-09-17
dc.description.abstract<p><i>Background</i>: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment.</p> <p><i>Methods</i>: The study was a longitudinal assessment of 124 patients (88 women and 36 men) in treatment at Modum Psychiatric Center, Norway. The patient sample comprised a mixed psychiatric population of whom 39 were diagnosed with posttraumatic stress disorder (PTSD). Serum blood samples for cytokine analysis and measures of mental distress using Global Severity Index were collected at admission (T0), halfway (T1), and before discharge (T2). Other factors assessed were age, gender, and the use of antidepressants and anti-inflammatory drugs. Multilevel modeling was used for longitudinal analyses to assess the repeated cytokine samples within each patient.</p> <p><i>Results</i>: Overall level of IL-1RA was higher in PTSD patients when compared to those without PTSD (P=0.021). The level of IL-1β, MCP-1, and TNF-α increased over time in PTSD compared to non-PTSD patients (P=0.025, P=0.011 and P=0.008, respectively). All patients experienced reduced mental distress as measured by self-reported Global Severity Index scores. Stratified analysis showed that PTSD patients who used anti-inflammatory drugs had higher levels of IL-1β (P=0.007) and TNF-α (P=0.049) than PTSD patients who did not use such drugs.</p> <p><i>Conclusion</i>: The study indicates that traumatized patients may have a distinct neuroimmune development during recovery. Their activated immune system shows even further activation during their rehabilitation despite symptom reduction.</p>en_US
dc.description.sponsorshipInnlandet Hospital Trust Health Region South-East Norwayen_US
dc.descriptionSource at <a href=https://doi.org/10.2147/NDT.S173659> https://doi.org/10.2147/NDT.S173659</a>.en_US
dc.identifier.citationToft, H.P., Bramness, J.G., Lien, L., Abebe, D.S.A., Wampold, B.E., Tilden, T.T., ... Neupane, S.P. (2018). PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress. <i>Neuropsychiatric Disease and Treatment, 14</i>, 2367-2378. https://doi.org/10.2147/NDT.S173659en_US
dc.identifier.cristinIDFRIDAID 1611058
dc.identifier.doi10.2147/NDT.S173659
dc.identifier.issn1176-6328
dc.identifier.issn1178-2021
dc.identifier.urihttps://hdl.handle.net/10037/14979
dc.language.isoengen_US
dc.publisherDove Medical Pressen_US
dc.relation.journalNeuropsychiatric Disease and Treatment
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry, child psychiatry: 757en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.subjectcytokinesen_US
dc.subjecttraumaen_US
dc.subjectinflammationen_US
dc.subjectPTSDen_US
dc.subjectimmune activationen_US
dc.titlePTSD patients show increasing cytokine levels during treatment despite reduced psychological distressen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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