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Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

Permanent link
https://hdl.handle.net/10037/15175
DOI
https://doi.org/10.1083/jcb.201711002
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Date
2018-07-17
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Larsen, Kenneth Bowitz; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje
Abstract
It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation elicit lysosomal degradation of up to 2–3% of the proteome. The most significant changes are caused by an immediate autophagic response elicited by shortage of amino acids but executed independently of mechanistic target of rapamycin and macroautophagy. Intriguingly, the autophagy receptors p62/SQSTM1, NBR1, TAX1BP1, NDP52, and NCOA4 are among the most efficiently degraded substrates. Already 1 h after induction of starvation, they are rapidly degraded by a process that selectively delivers autophagy receptors to vesicles inside late endosomes/multivesicular bodies depending on the endosomal sorting complex required for transport III (ESCRT-III). Our data support a model in which amino acid deprivation elicits endocytosis of specific membrane receptors, induction of macroautophagy, and rapid degradation of autophagy receptors by endosomal microautophagy.
Description
Source at https://doi.org/10.1083/jcb.201711002.
Publisher
Rockefeller University Press
Citation
Mejlvang, J., Olsvik, H., Svenning, S., Bruun, J.A., Abudu, Y.P., Larsen, K.B.L., ... Johansen T. (2018). Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. Journal of Cell Biology, 217(10), 3640-3655. https://doi.org/10.1083/jcb.201711002
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