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dc.contributor.authorHouwing, Danielle
dc.contributor.authorHeijkoop, Roy
dc.contributor.authorOlivier, Jocelien
dc.contributor.authorSnoeren, Eelke
dc.date.accessioned2019-04-12T13:42:29Z
dc.date.available2019-04-12T13:42:29Z
dc.date.issued2019-04-06
dc.description.abstractThe use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for the offspring remain largely unclear. Several studies have described potential effects of perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction of the behavior. For translational purposes it is important to take the environmental influences into account which children are exposed to in real life. By using a seminatural environmental set-up, this study is the first to assess behavioral outcomes in offspring exposed to perinatal SSRI exposure under seminatural circumstances. Mothers received daily the SSRI fluoxetine (FLX, 10 mg/kg p.o.) or vehicle (CTR) from gestational day 1 until postnatal day 21. To assess the effect of FLX exposure during early development, female and male offspring were behaviorally tested in the seminatural environment at adulthood. Baseline behavior was measured in addition to responses during and after stressful white-noise events. Behavior was observed on two days, day 4 on which females were sexually non-receptive, and day 7, on which females were sexual receptive. Perinatal FLX exposure reduced general activity in females and increased behavior related to a social context in both males and females. After a stressful white-noise event some behaviors switched. Whereas FLX-females switch from resting socially to resting more solitarily, FLX-males show an increase in self-grooming behavior after the stressor and showed more freezing behavior in the open area. We conclude that perinatal FLX exposure leads to alterations in social and stress-coping behaviors in adulthood, when observed in a seminatural environment. Whether these adaptations in behavior are advantageous or disadvantageous remains to be established.en_US
dc.description.sponsorshipHelse Nord #PFP1295-15, Norwayen_US
dc.descriptionAccepted manuscript, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a>Published version available at <a href=https://doi.org/10.1016/j.neuropharm.2019.03.037>https://doi.org/10.1016/j.neuropharm.2019.03.037. </a>en_US
dc.identifier.citationHouwing, D.J., Heijkoop, R., Olivier, J.D.A. & Snoeren, E.M.S. (2019). Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment. <i>Neuropharmacology, 151</i>, 84-97. https://doi.org/10.1016/j.neuropharm.2019.03.037en_US
dc.identifier.cristinIDFRIDAID 1691540
dc.identifier.doi10.1016/j.neuropharm.2019.03.037
dc.identifier.issn0028-3908
dc.identifier.issn1873-7064
dc.identifier.urihttps://hdl.handle.net/10037/15208
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalNeuropharmacology
dc.relation.projectIDHelse Nord RHF: PFP1295-16en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectAntidepressanten_US
dc.subjectFluoxetineen_US
dc.subjectPerinatalen_US
dc.subjectSocial behavioren_US
dc.subjectSexual behavioren_US
dc.subjectRatsen_US
dc.subjectSeminatural environmenten_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titlePerinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environmenten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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