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dc.contributor.authorLu, Chun-Li
dc.contributor.authorLui, Xue-han
dc.contributor.authorStub, Trine
dc.contributor.authorKristoffersen, Agnete Egilsdatter
dc.contributor.authorLiang, Shi-bing
dc.contributor.authorWang, Xiao
dc.contributor.authorBai, Xue
dc.contributor.authorNorheim, Arne Johan
dc.contributor.authorMusial, Frauke
dc.contributor.authorAlræk, Terje
dc.contributor.authorFønnebø, Vinjar
dc.contributor.authorLiu, Jianping
dc.date.accessioned2019-04-15T15:00:07Z
dc.date.available2019-04-15T15:00:07Z
dc.date.issued2018-09-26
dc.description.abstract<i>Background</i>: Due to limitations of conventional medicine for atopic eczema (AE), complementary and alternative medicine (CAM) is widely used as an alternative, maintaining, or simultaneous treatment for AE. We aimed to evaluate the beneficial and harmful effects of CAM for children with AE under 14 years old.<p> <p><i>Methods</i>: We searched for randomized trials on CAM in 12 Chinese and English databases from their inception to May 2018. We included children (< 14 years) diagnosed with AE, who received CAM therapy alone or combined with conventional medicine. We extracted data, and used the Cochrane “Risk of bias” tool to assess methodological quality. Effect was presented as relative risk (RR) or mean difference (MD) with 95% confidence interval (CI) using RevMan 5.3.<p> <p><i>Results</i>: Twenty-four randomized controlled trials involving 2233 children with AE were included. Methodological quality was of unclear or high risk of bias in general. The trials tested 5 different types of CAM therapies, including probiotics, diet, biofilm, borage oil, and swimming. Compared to placebo, probiotics showed improved effect for the SCORAD index (MD 9.01, 95% CI 7.12–10.90; <i>n</i> = 5). For symptoms and signs such as itching, skin lesions, CAM combined with usual care was more effective for symptom relief ≥95% (RR 1.47, 95% CI 1.30–1.68; <i>n</i> = 8), and for ≥50% symptoms improvement (RR 1.34, 1.25–1.45; <i>n</i> = 9) compared to usual care. There was no statistic significant difference between CAM and usual care on ≥95% improvement or ≥ 50% improvement of symptoms. However, swimming, diet and biofilm showed improvement of clinical symptoms compared with usual care. At follow-up of 8 weeks to 3 years, CAM alone or combined with usual care showed lower relapse rate (RR 0.38, 0.28–0.51, <i>n</i> = 2; RR 0.31, 0.24–0.40, <i>n</i> = 7; respectively) compared to usual care. Twelve out of 24 trials reported no occurrence of severe adverse events.<p> <p><i>Conclusions</i>: Low evidence demonstrates that some CAM modalities may improve symptoms of childhood AE and reduce relapse rate. Safety remains unclear due to insufficient reporting. Further well-designed randomized trials are needed to confirm the potential beneficial effect and to establish safety use.<p>en_US
dc.description.sponsorshipBeijing University of Chinese Medicineen_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12906-018-2306-6>https://doi.org/10.1186/s12906-018-2306-6. </a> © The Author(s). 2018en_US
dc.identifier.citationLu, C-L, Lui, X-H., Stub, T., Kristoffersen, A.E., Liang, S.B., Wang, X. ... Liu, J-P. (2018). Complementary and alternative medicine for treatment of atopic eczema in children under 14 years old: a systematic review and meta-analysis of randomized controlled trials. <i>BMC Complementary and Alternative Medicine</i>, 18:260. https://doi.org/10.1186/s12906-018-2306-6en_US
dc.identifier.cristinIDFRIDAID 1615657
dc.identifier.doi10.1186/s12906-018-2306-6
dc.identifier.issn1472-6882
dc.identifier.urihttps://hdl.handle.net/10037/15210
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Complementary and Alternative Medicine
dc.rights.accessRightsopenAccessen_US
dc.subjectComplementary and alternative medicineen_US
dc.subjectCAMen_US
dc.subjectAtopic eczemaen_US
dc.subjectChildrenen_US
dc.subjectRandomized controlled trialsen_US
dc.subjectSystematic reviewen_US
dc.subjectMeta-analysisen_US
dc.subjectClinical evidenceen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleComplementary and alternative medicine for treatment of atopic eczema in children under 14 years old: a systematic review and meta-analysis of randomized controlled trialsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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