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dc.contributor.authorStorjord, Elin
dc.contributor.authorDahl, Jim André
dc.contributor.authorLandsem, Anne
dc.contributor.authorLudviksen, Judith K
dc.contributor.authorKarlsen, Marlene
dc.contributor.authorKarlsen, Bård Ove
dc.contributor.authorBrekke, Ole-Lars
dc.date.accessioned2019-05-14T13:59:30Z
dc.date.available2019-05-14T13:59:30Z
dc.date.issued2018-12-10
dc.description.abstract<i>Background</i>: Lifestyle factors, including a low intake of carbohydrates, dieting, alcohol consumption, cigarette smoking and stress are some of the possible triggers of attacks in acute intermittent porphyria (AIP). The influence of lifestyle factors, including energy intake, diet and alcohol consumption on the biochemical disease activity in AIP and biochemical nutritional markers were examined.<p> <p><i>Methods</i>: A case-control study with 50 AIP cases and 50 controls matched for age, sex and place of residence was performed. Dietary intake was registered using a food diary in 46 matched pairs. Symptoms, alcohol intake, stress and other triggering factors of the last AIP attack were recorded on questionnaires. Porphyrin precursors, liver and kidney function markers, vitamins, diabetogenic hormones and other nutritional biomarkers were analyzed by routine methods. The Wilcoxon matched-pairs signed rank test was used to compare the cases vs. controls. The Spearman's rank correlation coefficient was used on the cases.<p> <p><i>Results</i>: Increasing total energy intake was negatively correlated with the biochemical disease activity. The intake of carbohydrates was lower than recommended, i.e., 40 and 39% of total energy intake in the AIP cases and controls, respectively. The plasma resistin level was significantly higher (p = .03) in the symptomatic than asymptomatic cases. Plasma insulin was lower in those with high porphobilinogen levels. The intake of sugar and candies were higher in the AIP cases with low U-delta aminolevulinic acid (ALA) levels (p = .04). Attacks were triggered by psychological stress (62%), physical strain (38%), food items (24%) and alcohol (32%) in the 34 symptomatic cases. Alcohol was used regularly by 88% of the cases (3.2 g ethanol/day) and 90% of the controls (6.3 g/day), but the intake was significantly lower in symptomatic than in asymptomatic cases (p = .045).<p> <p><i>Conclusion</i>: A high intake of energy, sugar and candies and a higher insulin level were associated with a lower biochemical disease activity. The resistin level was higher in the symptomatic than the asymptomatic cases. AIP patients drink alcohol regularly, but the intake was significantly lower in the symptomatic cases.<p>en_US
dc.description.sponsorshipNorthern, Regional Health Authorities Somatic research fund at the Nordland Hospital Trusten_US
dc.identifier.citationStorjord, E., Dahl, J.A., Landsem, A., Ludviksen, J.K., Karlsen, M.B., Karlsen, B.O. & Brekke, O-L. (2019). Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway. <i>Molecular Genetics and Metabolism, 128</i>(3), 254-270. https://doi.org/10.1016/j.ymgme.2018.12.006en_US
dc.identifier.cristinIDFRIDAID 1674366
dc.identifier.doi10.1016/j.ymgme.2018.12.006
dc.identifier.issn1096-7192
dc.identifier.issn1096-7206
dc.identifier.urihttps://hdl.handle.net/10037/15306
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofStorjord, E. (2021). Acute intermittent porphyria. Inflammation, diet and biomarkers in acute intermittent porphyria. (Doctoral thesis). <a href=https://hdl.handle.net/10037/20120>https://hdl.handle.net/10037/20120</a>
dc.relation.journalMolecular Genetics and Metabolism
dc.rights.accessRightsopenAccessen_US
dc.subjectDieten_US
dc.subjectAlcoholen_US
dc.subjectSmokingen_US
dc.subjectPorphyriaen_US
dc.subjectResistinen_US
dc.subjectHumanen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleLifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norwayen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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