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dc.contributor.authorHagen, Knut
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorNilsen, Kristian Bernhard
dc.date.accessioned2019-06-07T07:01:59Z
dc.date.available2019-06-07T07:01:59Z
dc.date.issued2019-03-12
dc.description.abstract<p><i>Background - </i>The relationship between high sensitivity C-reactive protein and migraine is unclear. The aim of this cross-sectional population-based study was to investigate the association between high sensitivity C-reactive protein and types of headache, and to evaluate the impact of insomnia on this association. <p><i>Methods - </i>A total of 20,486 (63%) out of 32,591 invited, aged ≥40 years or older, participated in the seventh wave of the Tromsø study conducted in 2015–2016 and had valid information on headache, insomnia and high sensitivity C-reactive protein. The influence of insomnia on the association between questionnaire-based diagnoses of headache and elevated high sensitivity C-reactive protein defined as >3.0 mg/L was assessed using multiple logistic regression, estimating prevalence odds ratio with 95% confidence intervals. <p><i>Results - </i>A total of 6290 participants (30.7%) suffered from headache during the last year. Among these, 1736 (8.5%) fulfilled the criteria of migraine, 991 (4.8%) had migraine with aura, 746 (3.6%) migraine without aura (3.8%), and 4554 (22.2%) had non-migrainous headache. In the final multi-adjusted analysis, elevated high sensitivity C-reactive protein was associated with headache (odds ratio 1.10, 95% confidence interval 1.01–1.20), migraine (odds ratio 1.17, 95% confidence interval 1.01–1.35), and migraine with aura (odds ratio 1.23, 95% confidence interval 1.01–1.53). No association was found between elevated high sensitivity C-reactive protein and migraine without aura or non-migrainous headache. The association between high sensitivity C-reactive protein and migraine was strongly dependent on insomnia status. Among individuals with insomnia, elevated high sensitivity C-reactive protein was associated with migraine (odds ratio 1.49, 95% confidence interval 1.02–2.17), and migraine with aura (odds ratio 1.59, 95% confidence interval 1.03–2.45), whereas no such relationship was found among those without insomnia. <p><i>Conclusions - </i>In this cross-sectional study, participants with migraine, in particular migraine with aura, were more likely to have elevated high sensitivity C-reactive protein, evident only among those with insomnia.en_US
dc.descriptionSource at <a href=https://doi.org/10.1177%2F0333102418825370>https://doi.org/10.1177%2F0333102418825370</a>.en_US
dc.identifier.citationHagen, K., Hopstock, L.A., Eggen, A.E., Mathiesen, E.B. & Nilsen, K.B. (2019). Does insomnia modify the association between C-reactive protein and migraine? The Tromsø Study 2015-2016. <i>Cephalalgia</i>. https://doi.org/10.1177%2F0333102418825370en_US
dc.identifier.cristinIDFRIDAID 1685770
dc.identifier.doi10.1177/0333102418825370
dc.identifier.issn0333-1024
dc.identifier.issn1468-2982
dc.identifier.urihttps://hdl.handle.net/10037/15477
dc.language.isoengen_US
dc.publisherSageen_US
dc.relation.journalCephalalgia
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectPopulation-baseden_US
dc.subjectCross-sectionalen_US
dc.subjectEpidemiologyen_US
dc.subjectDSM-Ven_US
dc.subjectHeadacheen_US
dc.titleDoes insomnia modify the association between C-reactive protein and migraine? The Tromsø Study 2015-2016.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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