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dc.contributor.authorLe Moëne, Olivia
dc.contributor.authorStavarache, Mihaela
dc.contributor.authorOgawa, Sonoko
dc.contributor.authorMusatov, Sergei
dc.contributor.authorÅgmo, Anders
dc.date.accessioned2019-06-26T08:31:15Z
dc.date.available2019-06-26T08:31:15Z
dc.date.issued2019-03-27
dc.description.abstractEstrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ERβ RNAs (or containing luciferase control) encoded within an adeno-associated viral vector, we silenced these receptors in the ventromedial nucleus of the hypothalamus (VMN) and the central amygdala (CeA). We exposed ovariectomized female rats, sequentially treated with estradiol benzoate and progesterone, to five stimuli, previously reported to elicit positive and negative affect. The subjects were housed in groups of 4 females and 3 males in a seminatural environment for several days before hormone treatment. We analyzed the frequency of a large number of behavior patterns. In addition, we performed analyses of co-occurrence in order to detect changes in the structure of behavior after infusion of the vectors. Silencing the ERα in the VMN disrupted lordosis and showed some anxiolytic properties in aversive situations, whereas silencing of the ERβ in this structure had no effect. This was also the case after silencing the ERα in the CeA. Silencing of the ERβ in this structure increased risk assessment, an expression of anxiety, and increased olfactory exploration of the environment. We hypothesize that the ERβ in the CeA has an important role in the well-established anxiolytic effects of estrogens, and that it may modulate arousal level. Furthermore, it seems that the ERα in the VMN is anxiogenic in aversive or threatening situations, in agreement with other studies.en_US
dc.description.sponsorshipFaculty of Health Sciences, University of Tromsøen_US
dc.identifier.citationLe Moëne, O., Stavarache, M., Ogawa, S., Musatov, S. & Ågmo, A. (2019). Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events. <i>Behavioural Brain Research, 367</i>, 128-142. https://doi.org/10.1016/j.bbr.2019.03.045en_US
dc.identifier.cristinIDFRIDAID 1694605
dc.identifier.doi10.1016/j.bbr.2019.03.045
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.urihttps://hdl.handle.net/10037/15606
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBehavioural Brain Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 The Authors.
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoophysiology and comparative physiology: 483en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Zoofysiologi og komparativ fysiologi: 483en_US
dc.subjectVentromedial nucleus of the hypothalamusen_US
dc.subjectCentral amygdalaen_US
dc.subjectRecoveryen_US
dc.subjectFearen_US
dc.subjectSeminatural environmenten_US
dc.subjectEstrogen receptorsen_US
dc.titleEstrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging eventsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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