Exploring N-nucleophiles for diversification of a complex cyclohexenone scaffold

Abstract

In this thesis, synthesis of 3 different dibenzylideneacetone (DBA)-analogues and 4 different ethyl 2-oxo-6-phenyl-4-(2-phenylethenyl)-4-cyclohexene-1-carboxylate-analogues that have not been reported before were synthesized, as well as a range of analogues that have been reported before. Both symmetrical and unsymmetrical DBA-analogues were made. The yields of many of these reactions were low, but with high potential within optimization, especially in work-up. Further on, the reactivity of the cyclohexenone scaffold molecule with phenylhydrazine was explored, and although products were not isolated, they were identified using NMR, and the reaction attempted optimized with the help of internal standard and NMR.