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dc.contributor.authorMoens, Ugo
dc.contributor.authorMacdonald, Andrew
dc.date.accessioned2019-09-17T08:10:17Z
dc.date.available2019-09-17T08:10:17Z
dc.date.issued2019-08-12
dc.description.abstractViruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the infected cell into a tumor cell. One mechanism viruses employ to reprogram the host cell is through interference with signaling pathways. Polyomaviruses are naked, double-stranded DNA viruses whose genome encodes the regulatory proteins large T-antigen and small t-antigen, and structural proteins that form the capsid. The large T-antigens and small t-antigens can interfere with several host signaling pathways. In this case, we review the interplay between the large T-antigens and small t-antigens with host signaling pathways and the biological consequences of these interactions.en_US
dc.description.sponsorshipUiT The Artic University of Norway (APC funding) The Kidney Research UK Helse Nord Olav and Erna Aakre Foundationen_US
dc.descriptionSource at <a href=https://doi.org/10.3390/ijms20163914>https://doi.org/10.3390/ijms20163914. </a>en_US
dc.identifier.citationMoens, U. & Macdonald, A. (2019). Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways. <i>International Journal of Molecular Sciences, 20</i>(16), 3914. https://doi.org/10.3390/ijms20163914en_US
dc.identifier.cristinIDFRIDAID 1718967
dc.identifier.doi10.3390/ijms20163914
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/16208
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectapoptosisen_US
dc.subjectDNA damage responseen_US
dc.subjectimmune responseen_US
dc.subjectinterferonen_US
dc.subjectMAP kinaseen_US
dc.subjectNFκBen_US
dc.subjectp53en_US
dc.subjectPI3Ken_US
dc.subjectprotein phosphatasesen_US
dc.subjectretinoblastomaen_US
dc.titleEffect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathwaysen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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