Show simple item record

dc.contributor.authorUeland, Thor
dc.contributor.authorStilgren, Lis
dc.contributor.authorBollerslev, Jens
dc.date.accessioned2019-09-17T13:16:16Z
dc.date.available2019-09-17T13:16:16Z
dc.date.issued2019-03-03
dc.description.abstractWnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST and Dickkopf-1 (DKK1) in combined extracts obtained after ethylenediaminetetraacetic acid and guanidine hydrochloride extraction in 56 postmenopausal women aged 47–74 (mean, 63) yr with a previous distal forearm fracture and a hip or spine Z-score less than 0. Our findings were (i) SOST and DKK1 protein levels were higher in trabecular bone, (ii) cortical and trabecular DKK1 and trabecular SOST correlated positively with bone matrix levels of osteocalcin (<i>r</i> between 0.28 and 0.45, <i>p</i> < 0.05), (iii) cortical DKK1 correlated with lumbar spine bone mineral density (BMD) (<i>r</i> = 0.32, <i>p</i> < 0.05) and femoral neck BMD (<i>r</i> = 0.41, <i>p</i> < 0.01), and (iv) cortical DKK1 and SOST correlated with apparent bone volumetric density and compressive strength (<i>r</i> between 0.34 and 0.51, <i>p</i> < 0.01). In conclusion, cortical bone matrix levels of DKK1 and SOST were positively correlated with bone mass and bone strength in postmenopausal osteoporotic women.en_US
dc.descriptionSource at <a href=https://doi.org/10.3390/ijms20122896>https://doi.org/10.3390/ijms20122896. </a>en_US
dc.identifier.citationUeland, T., Stilgren, L. & Bollerslev, J. (2019). Bone matrix levels of Dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosis. <i>International Journal of Molecular Sciences, 20</i>(12), 2896. https://doi.org/10.3390/ijms20122896en_US
dc.identifier.cristinIDFRIDAID 1723168
dc.identifier.doi10.3390/ijms20122896
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/16216
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectWnt signalingen_US
dc.subjectpostmenopausal osteoporosisen_US
dc.subjectbone matrix; bone massen_US
dc.subjectDickkopf-1en_US
dc.subjectsclerostinen_US
dc.titleBone matrix levels of Dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record