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dc.contributor.authorKjønås, Didrik
dc.contributor.authorDahle, Gry
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorMalm, Siri
dc.contributor.authorEidet, Jo
dc.contributor.authorAaberge, Lars
dc.contributor.authorSteigen, Terje
dc.contributor.authorAakhus, Svend
dc.contributor.authorBusund, Rolf
dc.contributor.authorRösner, Assami
dc.date.accessioned2019-10-04T20:48:07Z
dc.date.available2019-10-04T20:48:07Z
dc.date.issued2019-04-23
dc.description.abstract<p><i>Objectives - </i>To investigate whether preoperative echocardiographic evaluation of ventricular function, especially right ventricular systolic and diastolic parameters including speckle-tracking analysis, could aid in the prediction of 30-day mortality after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis. <p><i>Methods - </i>This is a prospective observational cohort study including 227 patients accepted for TAVI at the University Hospital of North Norway and Oslo University Hospital from February 2010 through June 2013. All patients underwent preoperative transthoracic echocardiography with retrospective speckle-tracking analysis. Primary endpoint was all-cause 30-day mortality. <p><i>Results - </i>All-cause 30-day mortality was 8.7 % (n = 19). Independent predictors of 30-day mortality were systolic pulmonary arterial pressure (SPAP) > 60 mm Hg (HR: 7.7, 95% CI: 1.90 to 31.3), heart failure (HR: 2.9, 95% CI: 1.1 to 7.78), transapical access (HR: 3.8, 95% CI: 1.3 to 11.2), peripheral artery disease (HR: 6.0, 95% CI: 2.0 to 18.0) and body mass index (HR: 0.73, 95% CI: 0.61 to 0.87). C-statistic for the model generated was 0.91 (95% CI: 0.85 to 0.98). Besides elevated SPAP, no other echocardiographic measurements were found to be an independent predictor of early mortality. <p><i>Conclusion - </i>Except for elevated systolic pulmonary artery pressure, our data suggests that clinical rather than echocardiographic parameters are useful predictors of 30-day mortality after TAVI.en_US
dc.description.sponsorshipRegional Health Authorities of North Norwayen_US
dc.identifier.citationKjønås D, Dahle G, Schirmer H, Malm S, Eidet J, Aaberge L, ... Rösner A. (2019). Predictors of early mortality after transcatheter aortic valve implantation. <i>Open heart, 6</i>(1), e000936. https://doi.org/10.1136/openhrt-2018-000936en_US
dc.identifier.cristinIDFRIDAID 1707170
dc.identifier.doi10.1136/openhrt-2018-000936
dc.identifier.issn2053-3624
dc.identifier.urihttps://hdl.handle.net/10037/16335
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofKjønås, D. (2022). Prediction of outcome in patients with severe aortic stenosis treated with transcatheter aortic valve implantation. (Doctoral thesis). <a href=https://hdl.handle.net/10037/25298>https://hdl.handle.net/10037/25298</a>.
dc.relation.journalOpen heart
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.titlePredictors of early mortality after transcatheter aortic valve implantationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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