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dc.contributor.authorCuminetti, Vincent
dc.contributor.authorArranz, Lorena
dc.date.accessioned2019-10-11T08:40:07Z
dc.date.available2019-10-11T08:40:07Z
dc.date.issued2019-05-18
dc.description.abstractBone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and functional responses, depending on their location in the BM. BMA also show remarkable differences among species and between genders, they progressively replace the hematopoietic BM throughout aging, and play roles in a range of pathological conditions such as obesity, diabetes and anorexia. They are a crucial component of the BM microenvironment that regulates hematopoiesis, through mechanisms largely unknown. Previously considered as negative regulators of hematopoietic stem cell function, recent data demonstrate their positive support for hematopoietic stem cells depending on the experimental approach. Here, we further discuss current knowledge on the role of BMA in hematological malignancies. Early hints suggest that BMA may provide a suitable metabolic niche for the malignant growth of leukemic stem cells, and protect them from chemotherapy. Future in vivo functional work and improved isolation methods will enable determining the true essence of this elusive BM hematopoietic stem cell niche component, and confirm their roles in a range of diseases. This promising field may open new pathways for efficient therapeutic strategies to restore hematopoiesis, targeting BMA.en_US
dc.description.sponsorshipNorthern Norway Regional Health Authority University Hospital of Northern Norway (UNN) UiT The Arctic University of Norway Norwegian Cancer Society Aakre-Stiftelsen Foundationen_US
dc.descriptionSource at <a href=https://doi.org/10.3390/jcm8050707>https://doi.org/10.3390/jcm8050707</a>.en_US
dc.identifier.citationCuminetti, V. & Arranz, L. (2019). Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche. <i>Journal of Clinical Medicine, 8</i>(5), 707. https://doi.org/10.3390/jcm8050707en_US
dc.identifier.cristinIDFRIDAID 1700192
dc.identifier.doi10.3390/jcm8050707
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/10037/16374
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalJournal of clinical medicine
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/247596/Norway/Neuroglial Regulation of the Haematopoietic Stem Cell Niche in Acute Myeloid Leukaemia Transformation//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/250901/Norway/Stem Cell Metabolic Dysfunction in Myeloid Leukaemia and its Therapeutic Targeting//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Human and veterinary science physiology: 718en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Human og veterinærmedisinsk fysiologi: 718en_US
dc.subjectBone marrow adipocytesen_US
dc.subjectmesenchymal stromal cellsen_US
dc.subjecthematopoietic stem cellsen_US
dc.subjecthematopoietic stem cell nicheen_US
dc.subjecthematopoiesisen_US
dc.subjecthematopoietic malignanciesen_US
dc.subjectmetabolismen_US
dc.titleBone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Nicheen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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