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dc.contributor.authorJørgensen, Silje Fjellgård
dc.contributor.authorMacpherson, Magnhild Eide
dc.contributor.authorBjørnetrø, Tonje
dc.contributor.authorHolm, Kristian
dc.contributor.authorKummen, Martin
dc.contributor.authorRashidi, Azita
dc.contributor.authorMichelsen, Annika
dc.contributor.authorLekva, Tove
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorTrøseid, Marius
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorBerge, Rolf Kristian
dc.contributor.authorYndestad, Arne
dc.contributor.authorUeland, Thor
dc.contributor.authorKarlsen, Tom Hemming
dc.contributor.authorAukrust, Pål
dc.contributor.authorHov, Johannes Espolin Roksund
dc.contributor.authorFevang, Børre
dc.date.accessioned2019-10-15T13:36:38Z
dc.date.available2019-10-15T13:36:38Z
dc.date.issued2019-01-17
dc.description.abstractCommon variable immunodeficiency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic inflammation and ten “key” bacteria that capture the gut dysbiosis (dysbiosis index) in CVID. Rifaximin is a broad-spectrum non-absorbable antibiotic known to reduce gut leakage (lipopolysaccharides, LPS) in liver disease. In this study, we explored as a ‘proof of concept’ that altering gut microbial composition could reduce systemic inflammation, using CVID as a disease model. Forty adult CVID patients were randomized, (1:1) to twice-daily oral rifaximin 550 mg versus no treatment for 2 weeks in an open-label, single-centre study. Primary endpoints were reduction in plasma/serum levels of soluble (s) CD14, sCD25, sCD163, neopterin, CRP, TNF, LPS and selected cytokines measured at 0, 2 and 8 weeks. Secondary endpoint was changes in intra-individual bacterial diversity in stool samples. Rifaximin-use did not significantly change any of the inflammation or gut leakage markers, but decreased gut microbial diversity compared with no treatment (p = 0.002). Importantly, the gut bacteria in the CVID dysbiosis index were not changed by rifaximin. The results suggest that modulating gut microbiota by rifaximin is not the chosen intervention to affect systemic inflammation, at least not in CVID.en_US
dc.descriptionSource at <a href=https://doi.org/10.1038/s41598-018-35367-7>https://doi.org/10.1038/s41598-018-35367-7</a>.en_US
dc.identifier.citationJørgensen, S.F., Macpherson, M.E., Bjørnetrø, T., Holm, K., Kummen, M., Rashidi, A., ... Fevang, B. (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. <i>Scientific Reports, 9</i>, 167. https://doi.org/10.1038/s41598-018-35367-7en_US
dc.identifier.cristinIDFRIDAID 1692689
dc.identifier.doi10.1038/s41598-018-35367-7
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/16403
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalScientific Reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/240787/Norway/Exploring the metabolic signatures of disease and drug associated genomic features of the gut microbiota in Norway/NORGUT/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectImmunological deficiency syndromesen_US
dc.subjectMicrobiotaen_US
dc.titleRifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiencyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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