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dc.contributor.authorDossus, Laure
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorBiessy, Carine
dc.contributor.authorNavionis, Anne-Sophie
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorScalbert, Augustin
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorFournier, Agnès
dc.contributor.authorFortner, Renée Turzanski
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorPeppa, Eleni
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salavatore
dc.contributor.authorPalli, Domenico
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorVineis, Paolo
dc.contributor.authorBueno-de-Mesquita, Hendrik Bastiaan
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorSkeie, Guri
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorQuirós, Jose Ramón
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorSandström, Maria
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorSchmidt, Julie A.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorRinaldi, Sabina
dc.date.accessioned2019-10-23T13:44:17Z
dc.date.available2019-10-23T13:44:17Z
dc.date.issued2017-11-23
dc.description.abstractOther than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C‐reactive protein, interleukin (IL)‐6, IL‐10 and tumor necrosis factor (TNF)‐α and the risk of TC. A case‐control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer‐free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (OR<sub>T3vs.T1</sub> = 0.69, 95% CI: 0.49–0.98, <i>P</i><sub>trend</sub> = 0.04) but not among men (OR<sub>T3vs.T1</sub> = 1.36, 95% CI: 0.67–2.76, <i>P</i><sub>trend</sub> = 0.37). Increasing levels of IL‐10 were positively associated with TC risk in both genders and significantly so in women (OR<sub>T3vs.T1</sub> = 1.59, 95% CI: 1.13–2.25, <i>P</i><sub>trend</sub> = 0.01) but not in men (OR<sub>T3vs.T1</sub> = 1.78, 95% CI: 0.80–3.98, <i>P</i><sub>trend</sub> = 0.17). Leptin, CRP, IL‐6 and TNF‐α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL‐10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.en_US
dc.descriptionSource at <a href=https://doi.org/10.1002/ijc.31172>https://doi.org/10.1002/ijc.31172</a>.en_US
dc.identifier.citationDossus, L., Franceschi, S., Biessy, C., Navionis, A.S,. Travis, R.C., Weiderpass, E., ... Rinaldi, S. (2018). Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study. <i>International Journal of Cancer, 142</i>(7), 1332-1342. https://doi.org/10.1002/ijc.31172en_US
dc.identifier.cristinIDFRIDAID 1591968
dc.identifier.doi10.1002/ijc.31172
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/16460
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectthyroid canceren_US
dc.subjectinflammationen_US
dc.subjectcytokineen_US
dc.subjectadipokineen_US
dc.subjectprospective cohorten_US
dc.titleAdipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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