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dc.contributor.authorDahm, Anders Erik A
dc.contributor.authorJacobsen, Eva-Marie
dc.contributor.authorWik, Hilde Skuterud
dc.contributor.authorJacobsen, Anne Flem
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorKanse, Sandip
dc.contributor.authorSandset, Per Morten
dc.date.accessioned2019-11-04T09:28:13Z
dc.date.available2019-11-04T09:28:13Z
dc.date.issued2019-06-29
dc.description.abstractHigh levels of complement C3 are associated with venous thrombosis (VT) in the general population. We investigated if high C3 and C4 levels were associated with pregnancy-related VT. We undertook the Norwegian VIP study, a case–control study of VT in pregnancy or within 3 months postpartum (cases, n = 313) and women without pregnancy-related VT (controls, <i>n</i> = 353). Determinants of C3 and C4 in the control women were investigated with linear regression and the odds ratio (OR) for pregnancy-related VT was calculated with logistic regression. We found that levels of C3 and C4 were associated with body mass index (BMI), C-reactive protein (CRP); with the coagulation factors (F) fibrinogen, FVIII, and FIX; and with the coagulation inhibitors antithrombin, protein C, protein S, and tissue factor pathway inhibitor. These associations were influenced by CRP levels. The crude OR for pregnancy-related VT was 1.8 (95% confidence interval [CI], 1.1–3.0) for C3 above the 90th percentile and 2.0 (95% CI, 1.2–3.2) for C4 above the 90th percentile. Stratification in antenatal and postnatal VT showed that C3 and C4 were only associated with postnatal VT with an OR for high C3 of 3.0 (95% CI, 1.8–5.0), and for high C4 of 2.6 (95% CI, 1.5–4.6). Adjustment for high FIX and BMI reduced the ORs. We conclude that the association between postnatal VT and C3 and C4 suggests that there is clinically relevant crosstalk between the complement and the coagulation system.en_US
dc.descriptionAccepted manuscript. Final version published in <i>Thrombosis and Haemostasis, 119</i>(09), 1481-1488, is available at <a href=https://doi.org/10.1055/s-0039-1692426>https://doi.org/10.1055/s-0039-1692426. </a>en_US
dc.identifier.citationDahm, A.E.A., Jacobsen, E.M., Wik, H.S., Jacobsen, A.F., Mollnes, T.E., Kanse, S. & Sandset, P.M. (2019). Elevated complement C3 and C4 levels are associated with postnatal pregnancy-related venous thrombosis. <i>Thrombosis and Haemostasis, 119</i>(9), 1481-1488. https://doi.org/10.1055/s-0039-1692426en_US
dc.identifier.cristinIDFRIDAID 1740604
dc.identifier.doi10.1055/s-0039-1692426
dc.identifier.issn0340-6245
dc.identifier.urihttps://hdl.handle.net/10037/16587
dc.language.isoengen_US
dc.publisherThieme Publishingen_US
dc.relation.journalThrombosis and Haemostasis
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMED/160805/Norway/Venous thromboembolism in pregnancy//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleElevated complement C3 and C4 levels are associated with postnatal pregnancy-related venous thrombosisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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