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dc.contributor.authorNeupane, Sudan Prasad
dc.contributor.authorLien, Lars
dc.contributor.authorMartinez, Priscilla
dc.contributor.authorAukrust, Pål
dc.contributor.authorUeland, Thor
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHestad, Knut
dc.contributor.authorBramness, Jørgen Gustav
dc.date.accessioned2019-11-09T14:24:17Z
dc.date.available2019-11-09T14:24:17Z
dc.date.issued2014-07-03
dc.description.abstract<p><i>Aims - </i>As major depression (MD) is often comorbid with alcohol‐use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)‐6, IL‐10, tumor necrosis factor (TNF), and interferon (IFN)‐γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. <p><i>Methods - </i>A consecutive sample of inpatients with AUD (N = 176) from eight alcohol treatment centers in Kathmandu, Nepal, was assessed for alcohol use and depression by administering fully structured psychiatric interviews. Serum cytokine levels were determined using multiplex technology. <p><i>Results - </i>Alcohol‐use disorders patients with a positive history of MD had higher levels of the inflammatory cytokines IL‐6 (P = 0.019), TNF (P = 0.020), and IFN‐γ (P = 0.001), but not of IL‐10 (P = 0.853). AUD patients with MD had higher concentrations of cytokines compared with those without, regardless of the severity of the alcohol problem, but the difference was greater among those drinking in lower frequency and intensity. <p><i>Conclusion - </i>These findings provide evidence for altered functioning of the immune system in AUD patients with comorbid MD. However, frequent and intense drinking may attenuate the difference in the cytokine profiles between AUD patients with and without MD.en_US
dc.descriptionSource at <a href=https://doi.org/10.1111/cns.12303>https://doi.org/10.1111/cns.12303</a>.en_US
dc.identifier.citationNeupane, S.P., Lien, L., Martinez, P., Aukrust, P., Ueland, T., Mollnes, T.E., Hestad, K. & Bramness, J.G. (2014). High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders. <i>CNS Neuroscience & Therapeutics, 20</i>(10), 898-904. https://doi.org/10.1111/cns.12303en_US
dc.identifier.cristinIDFRIDAID 1136239
dc.identifier.doi10.1111/cns.12303
dc.identifier.issn1755-5930
dc.identifier.issn1755-5949
dc.identifier.urihttps://hdl.handle.net/10037/16638
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalCNS Neuroscience & Therapeutics
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Midical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801en_US
dc.titleHigh frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disordersen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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