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dc.contributor.authorDenker, Elsa
dc.contributor.authorEbbesson, Lars O.E.
dc.contributor.authorHazlerigg, David
dc.contributor.authorMacqueen, Daniel J.
dc.date.accessioned2019-12-09T14:06:05Z
dc.date.available2019-12-09T14:06:05Z
dc.date.issued2019-10-01
dc.description.abstractThe circadian and seasonal actions of melatonin are mediated by high affinity G-protein coupled receptors (melatonin receptors, MTRs), classified into phylogenetically distinct subtypes based on sequence divergence and pharmacological characteristics. Three vertebrate MTR subtypes are currently described: MT1 (MTNR1A), MT2 (MTNR1B), and Mel1c (MTNR1C / GPR50), which exhibit distinct affinities, tissue distributions and signaling properties. We present phylogenetic and comparative genomic analyses supporting a revised classification of the vertebrate MTR family. We demonstrate four ancestral vertebrate MTRs, including a novel molecule hereafter named Mel1d. We reconstructed the evolution of each vertebrate MTR, detailing genetic losses in addition to gains resulting from whole genome duplication events in teleost fishes. We show that Mel1d was lost separately in mammals and birds and has been previously mistaken for an MT1 paralogue. The genetic and functional diversity of vertebrate MTRs is more complex than appreciated, with implications for our understanding of melatonin actions in different taxa. The significance of our findings, including the existence of Mel1d, are discussed in an evolutionary and functional context accommodating a robust phylogenetic assignment of MTR gene family structure.en_US
dc.identifier.citationDenker E, Ebbesson L, Hazlerigg D, Macqueen DJ. Phylogenetic Reclassification of Vertebrate Melatonin Receptors To Include Mel1d. G3: Genes, Genomes, Genetics. 2019;9(10):3225-3238en_US
dc.identifier.cristinIDFRIDAID 1740009
dc.identifier.doi10.1534/g3.119.400170
dc.identifier.issn2160-1836
dc.identifier.urihttps://hdl.handle.net/10037/16853
dc.language.isoengen_US
dc.publisherGenetics Society of Americaen_US
dc.relation.journalG3: Genes, Genomes, Genetics
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/241016/Norway/Light & Salt - Thyroid hormone deiodinase paralogues & the evolution of complex life-history strategy in salmonids//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Systematic zoology: 487en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Systematisk zoologi: 487en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoophysiology and comparative physiology: 483en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Zoofysiologi og komparativ fysiologi: 483en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Molecular biology: 473en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.titlePhylogenetic Reclassification of Vertebrate Melatonin Receptors To Include Mel1den_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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