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dc.contributor.authorHessen, Erik
dc.contributor.authorKirsebom, Bjørn-Eivind
dc.contributor.authorEriksson, Cecilia Magdalena
dc.contributor.authorEliassen, Carl Fredrik Andestad
dc.contributor.authorNakling, Arne
dc.contributor.authorBråthen, Geir
dc.contributor.authorWaterloo, Knut
dc.contributor.authorAarsland, Dag
dc.contributor.authorFladby, Tormod
dc.date.accessioned2019-12-10T10:11:17Z
dc.date.available2019-12-10T10:11:17Z
dc.date.issued2019-01-22
dc.description.abstract<i>Background:</i> In the care of persons with cognitive problems, it is important to use a valid mild cognitive impairment (MCI) criterion that discriminates well between normal and pathological aging.<p> <p><i>Objective:</i> To find the brief neuropsychological screening criterion that best correlates with cerebrospinal fluid (CSF) biomarkers for cognitive decline and dementia in persons seeking help for cognitive problems.<p> <p><i>Methods:</i> 452 consecutively recruited patients (age 40–80 years) from memory-clinics in the Norwegian national multicentre longitudinal study Dementia Disease Initiation were included. CSF data as well as full data from brief neuropsychological screening were available for all patients.<p> <p><i>Results:</i> Amnestic MCI, including at least one memory test below T-score 40, outperformed the conventional US National Institute on Aging-Alzheimer’s Association (NIA-AA) MCI criterion. Only amnestic MCI was significantly associated with biomarker pattern of NIA-AA stage 2 (low CSF Aβ42 concentrations and elevated tau) in multivariate regression analysis.<p> <p><i>Conclusions:</i> The finding that amnestic MCI based on brief neuropsychological assessment is significantly associated with CSF biomarkers for cognitive decline and Alzheimer’s disease is in accordance with longitudinal studies that find memory impairment; both in itself and especially in combination with other cognitive deficit to constitute a risk factor for subsequent cognitive decline and dementia. The prevalence of pathological biomarkers for Alzheimer’s disease is common in the elderly and the clinical significance of present findings depend on longitudinal validation.en_US
dc.identifier.citationHessen E, Kirsebom BE, Eriksson CM, Eliassen CFA, Nakling A, Bråthen GBr, Waterloo K, Aarsland D, Fladby T. In Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterion. Journal of Alzheimer's Disease. 2019;67(2):715-723en_US
dc.identifier.cristinIDFRIDAID 1689919
dc.identifier.doi10.3233/JAD-180964
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.urihttps://hdl.handle.net/10037/16865
dc.language.isoengen_US
dc.publisherIOS Pressen_US
dc.relation.journalJournal of Alzheimer's Disease
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titleIn Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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