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dc.contributor.authorGiordani, Barbara
dc.contributor.authorBasnet, Purusotam
dc.contributor.authorMishchenko, Ekaterina
dc.contributor.authorLuppi, Barbara
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2020-01-03T10:33:39Z
dc.date.available2020-01-03T10:33:39Z
dc.date.issued2019-12-20
dc.description.abstractVulvovaginal candidiasis (VVC) is a widely spread fungal infection that causes itching, pain and inflammation at the vaginal site. Although common, currently available treatment suffers from limited efficacy and high recurrence. In addition, the growing problem of resistance to azole drugs used in current treatments emphasizes the need for superior treatment options. Antimicrobial polyphenols are an attractive approach offering multitargeting therapy. We aimed to develop novel liposomes for simultaneous delivery of two polyphenols (quercetin, Q, and gallic acid, GA) that, when released within the vaginal cavity, act in synergy to eradicate infection while alleviating the symptoms of VVC. Q was selected for its anti-itching and anti-inflammatory properties, while GA for its reported activity against <i>Candida.</i> Novel liposomes containing only Q (LP-Q), only GA (LP-GA) or both polyphenols (LP-Q+GA) were in the size range around 200 nm. Q was efficiently entrapped in both LP-Q and in LP-Q+GA (85%) while the entrapment of GA was higher in LP-Q+GA (30%) than in LP-GA (25%). Liposomes, especially LP-Q+GA, promoted sustained release of both polyphenols. Q and GA acted in synergy, increasing the antioxidant activities of a single polyphenol. Polyphenol-liposomes were not cytotoxic and displayed stronger anti-inflammatory effects than free polyphenols. Finally, LP-GA and LP-Q+GA considerably reduced C. <i>albicans</i> growth.en_US
dc.identifier.citationGiordani, Basnet, Mishchenko, Luppi, Skalko-Basnet. Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections. Pharmaceutics. 2020en_US
dc.identifier.cristinIDFRIDAID 1764305
dc.identifier.doi10.3390/pharmaceutics12010009
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10037/17015
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalPharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleUtilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infectionsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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