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dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorIsaksen, Trond
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2020-01-08T14:33:01Z
dc.date.available2020-01-08T14:33:01Z
dc.date.issued2019-04-15
dc.description.abstract<i>Background</i> - Limited data exist on the relationship between physical activity and major complications after incident venous thromboembolism (VTE).<p> <p><i>Objectives</i> - To investigate whether physical activity was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p><i>Methods</i> - Patients with incident VTE (n = 786) derived from the Tromsø Study surveys 4‐6 (1994‐1995, 2001‐2002, and 2007‐2008) were included, and data on physical activity were dichotomized according to the activity level reported in the survey preceding the incident VTE (inactive: <1 hour per week, active: ≥1 hour per week). Recurrent VTE and all‐cause mortality were registered up to December 31, 2015. Hazard ratios (HRs) for recurrence and all‐cause mortality were calculated using Cox regression models with the inactive group as reference.<p> <p><i>Results</i> - There were 139 recurrences and 395 deaths during follow‐up. Physical activity was not associated with the risk of recurrence in men (HR model 2: 1.48, 95% confidence interval [CI] 0.83‐2.65) or in women (HR model 2: 0.95, 95% CI 0.52‐1.74). In contrast, physical activity was associated with a 28% lower risk of mortality during 10 years of follow up (HR model 3: 0.72, 95% CI 0.57‐0.91). The inverse association was stronger in patients with a first deep vein thrombosis ( HR model 2: 0.59, 95% CI 0.44‐0.79) than a pulmonary embolism (HR model 3: 0.87, 95% CI 0.61‐1.26).<p> <p><i>Conclusion</i> - Our results suggest that habitual physical activity prior to incident VTE does not influence the risk of recurrence. In contrast, active individuals were at lower risk of mortality, particularly following deep vein thrombosis.en_US
dc.descriptionThis is the peer reviewed version of the following article: Evensen, L.H., Isaksen, T., Brækkan, S.K. & Hansen, J.-B. (2019). Physical activity and risk of recurrence and mortality after incident venous thromboembolism. <i>Journal of thrombosis and haemostasis, 17</i>(6), 901-911, which has been published in final form at <a href=https://doi.org/10.1111/jth.14449>https://doi.org/10.1111/jth.14449 </a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationEvensen L, Isaksen T, Brækkan SK, Hansen JB. Physical activity and risk of recurrence and mortality after incident venous thromboembolism. Journal of Thrombosis and Haemostasis. 2019;17(6):901-911en_US
dc.identifier.cristinIDFRIDAID 1693366
dc.identifier.doi10.1111/jth.14449
dc.identifier.issn1538-7933
dc.identifier.issn1538-7836
dc.identifier.urihttps://hdl.handle.net/10037/17036
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofFinal version of this paper is part of:<p> <p>Evensen, L.H. (2020). Physical activity, cardiorespiratory fitness and venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/18072>https://hdl.handle.net/10037/18072.</a>
dc.relation.journalJournal of Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 International Society on Thrombosis and Haemostasisen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titlePhysical activity and risk of recurrence and mortality after incident venous thromboembolismen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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