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dc.contributor.authorVillela, Darine
dc.contributor.authorChe, Huiwen
dc.contributor.authorVan Ghelue, Marijke
dc.contributor.authorDehaspe, Luc
dc.contributor.authorBrison, Nathalie
dc.contributor.authorVan Den Bogaert, Kris
dc.contributor.authorDevriendt, Koen
dc.contributor.authorLewi, Liesbeth
dc.contributor.authorBayindir, Baran
dc.contributor.authorVermeesch, Joris Robert
dc.date.accessioned2020-01-10T10:04:15Z
dc.date.available2020-01-10T10:04:15Z
dc.date.issued2019-07-04
dc.description.abstractNon-invasive prenatal testing (NIPT) is accurate for fetal sex determination in singleton pregnancies, but its accuracy is not well established in twin pregnancies. Here, we present an accurate sex prediction model to discriminate fetal sex in both dichorionic diamniotic (DCDA) and monochorionic diamniotic/monochorionic monoamniotic (MCDA/MCMA) twin pregnancies. A retrospective analysis was performed using a total of 198 twin pregnancies with documented sex. The prediction was based on a multinomial logistic regression using the normalized frequency of X and Y chromosomes, and fetal fraction estimation. A second-step regression analysis was applied when one or both twins were predicted to be male. The model determines fetal sex with 100% sensitivity and specificity when both twins are female, and with 98% sensitivity and 95% specificity when a male is present. Since sex determination can be clinically important, implementing fetal sex determination in twins will improve overall twin pregnancies management.en_US
dc.identifier.citationVillela, Che, Van Ghelue GM, Dehaspe, Brison, Van Den Bogaert, Devriendt K, Lewi L, Bayindir, Vermeesch JR. Fetal sex determination in twin pregnancies using non-invasive prenatal testing. NPJ GENOMIC MEDICINE. 2019;4(1)en_US
dc.identifier.cristinIDFRIDAID 1719518
dc.identifier.doi10.1038/s41525-019-0089-4
dc.identifier.issn2056-7944
dc.identifier.urihttps://hdl.handle.net/10037/17055
dc.language.isoengen_US
dc.publisherSpringer Verlagen_US
dc.relation.journalNPJ GENOMIC MEDICINE
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleFetal sex determination in twin pregnancies using non-invasive prenatal testingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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