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dc.contributor.authorDiab, Joseph
dc.contributor.authorHansen, Terkel
dc.contributor.authorGoll, Rasmus
dc.contributor.authorStenlund, Hans
dc.contributor.authorJensen, Einar
dc.contributor.authorMoritz, Thomas
dc.contributor.authorFlorholmen, Jon
dc.contributor.authorForsdahl, Guro
dc.date.accessioned2020-01-16T14:02:54Z
dc.date.available2020-01-16T14:02:54Z
dc.date.issued2019-11-27
dc.description.abstractThe onset of ulcerative colitis (UC) is characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host–microbe interaction. This complexity makes UC ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient stratification strategies. This study aims to explore the mucosal metabolomic profile in UC patients, and to define the UC metabolic signature. Treatment- naïve UC patients (<i>n</i> = 18), UC patients in deep remission (<i>n</i> = 10), and healthy volunteers (<i>n</i> = 14) were recruited. Mucosa biopsies were collected during colonoscopies. Metabolomic analysis was performed by combined gas chromatography coupled to time-of-flight mass spectrometry (GC-TOF-MS) and ultra-high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS). In total, 177 metabolites from 50 metabolic pathways were identified. The most prominent metabolome changes among the study groups were in lysophosphatidylcholine, acyl carnitine, and amino acid profiles. Several pathways were found perturbed according to the integrated pathway analysis. These pathways ranged from amino acid metabolism (such as tryptophan metabolism) to fatty acid metabolism, namely linoleic and butyrate. These metabolic changes during UC reflect the homeostatic disturbance in the gut, and highlight the importance of system biology approaches to identify key drivers of pathogenesis which prerequisite personalized medicine.en_US
dc.identifier.citationDiab J, Hansen T, Goll r, Stenlund H, Jensen e, Moritz T, Florholmen J, Forsdahl G. Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis. Metabolites. 2019;9en_US
dc.identifier.cristinIDFRIDAID 1770610
dc.identifier.doi10.3390/metabo9120291
dc.identifier.issn2218-1989
dc.identifier.urihttps://hdl.handle.net/10037/17121
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofDiab, J. (2020). The Metabolome and Lipidome of Ulcerative Colitis. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19449>https://hdl.handle.net/10037/19449</a>.
dc.relation.journalMetabolites
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleMucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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