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dc.contributor.authorGrimnes, Guri
dc.contributor.authorKubiak, Julia Magdalena
dc.contributor.authorJorde, Rolf
dc.date.accessioned2020-01-20T08:48:24Z
dc.date.available2020-01-20T08:48:24Z
dc.date.issued2019-12-16
dc.description.abstract<i>Main objective</i> - The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at baseline.<p> <p><i>Methods</i> - 417 men and women aged 40–80 years were included and randomized to receive a loading dose of 100 000 IU (2500 ug) vitamin D3 followed by 20 000 IU (500 ug)/week, or placebo. Muscle strength was tested by dynamometers at baseline and after four months.<p> <p><i>Results</i> - Serum 25(OH)D levels increased from 32.6±11.1 nmol/l to 88.8±19.4 nmol/l (p<0.01) in the vitamin D group, while remaining low in the placebo group (baseline and final levels at 35.1±13.6 nmol/l and 30.7 ±9.7 nmol/l respectively). Muscle strength (hip flexion, biceps flexion, pectorals and handgrip strength) did not change in any of the groups. The results were the same in analyses stratified on sex, 25(OH)D above/below 25 nmol/L (10 ng/ml); smoking status; and BMI above/below 27 kg/m2.<p> <p><i>Conclusion</i> These data does not support vitamin D supplementation for improving muscle strength.en_US
dc.identifier.citationGrimnes G, Kubiak JM, Jorde r. Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial. PLOS ONE. 2019;14(12)en_US
dc.identifier.cristinIDFRIDAID 1774387
dc.identifier.doi10.1371/journal.pone.0225600
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/17137
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLOS ONE
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleFour months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trialen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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