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dc.contributor.authorDi Cagno, Massimiliano Pio
dc.contributor.authorStein, Paul C
dc.date.accessioned2020-01-22T13:20:06Z
dc.date.available2020-01-22T13:20:06Z
dc.date.issued2019-04-04
dc.description.abstractAn experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and liposomes) on the passive diffusion of four active pharmaceutical ingredients (API) of different nature (hydrophilic, ionizable and lipophilic) through an unstirred water layer (UWL) model. This approach allowed the measurement of flux changes through the UWL and the computational calculation of different parameters relevant to interpret the interplay within solubilizing vehicles and UWL diffusion. In the case of cyclodextrin, this approach allowed the determination of free drug diffusivity (D<sub>f</sub>), bound drug diffusivity (D<sub>b</sub>) and the equilibrium constant (K). In the case of liposomes, the experimental approach allowed the determination of the liposomes/water partition coefficient (P<sub>lip/w</sub>) as well as relative API diffusivity ((D), i.e. the drug diffusion in the presence of solubilizing agents). This work demonstrates that the presence of solubilizing vehicles hampers the diffusion of API through UWL due to a combination of reduction in relative diffusivity and concentration gradient. These results are highly relevant as they might help to explain why biological performance of API is affected by the presence of solubilizing/complexing agents.en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a>en_US
dc.identifier.citationDi Cagno MP, Stein PC. Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy. European journal of pharmaceutics and biopharmaceutics. 2019;139:205-212en_US
dc.identifier.cristinIDFRIDAID 1690753
dc.identifier.doi10.1016/j.ejpb.2019.04.005
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.urihttps://hdl.handle.net/10037/17183
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean journal of pharmaceutics and biopharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 Elsevier B.V. All rights reserved.en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleStudying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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