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dc.contributor.authorLergenmuller, Simon
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorRobsahm, Trude Eid
dc.contributor.authorGreen, Adele C.
dc.contributor.authorLund, Eiliv
dc.contributor.authorRueegg, Corina Silvia
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2020-02-03T10:04:18Z
dc.date.available2020-02-03T10:04:18Z
dc.date.issued2019-10-02
dc.description.abstract<i>Importance</i> - No study, to our knowledge, has prospectively investigated a dose-response association between lifetime indoor tanning and risk of cutaneous squamous cell carcinoma (SCC).<p> <p><i>Objective</i> - To investigate the dose-response association between lifetime indoor tanning and SCC risk, the association between duration of use and age at initiation with SCC risk, and the association between age at initiation and age at diagnosis.<p> <p><i>Design, Setting, and Participants</i> - This cohort study included data from women born from 1927 to 1963 from the Norwegian Women and Cancer study, established in 1991 with follow-up through December 31, 2015. Baseline questionnaires were issued to participants from 1991 to 2007, with follow-up questionnaires given every 5 to 7 years. Data analysis was performed from January 2, 2018, to March 2, 2019.<p> <p><i>Exposures</i> - Participants reported pigmentation factors. Sunburns, sunbathing vacations, and indoor tanning were reported for childhood, adolescence, and adulthood.<p> <p><i>Main Outcomes and Measures</i> - Information on all cancer diagnoses and dates of emigration or death were obtained through linkage to the Cancer Registry of Norway, using the unique personal identification number of Norwegian citizens.<p> <p><i>Results</i> - A total of 159 419 women (mean [SD] age at inclusion, 49.9 [8.3] years) were included in the study. During follow-up (mean [SD], 16.5 [6.4] years), 597 women were diagnosed with SCC. Risk of SCC increased with increasing cumulative number of indoor tanning sessions. The adjusted hazard ratio (HR) for highest use vs never use was 1.83 (95% CI, 1.38-2.42; <i>P</i> < .001 for trend). A significantly higher risk of SCC was found among women with 10 years or less of use (HR, 1.41; 95% CI, 1.08-1.85) and more than 10 years of use (HR, 1.43; 95% CI, 1.16-1.76) and among women with age at initiation of 30 years or older (HR, 1.36; 95% CI, 1.11-1.67) and younger than 30 years (HR, 1.51; 95% CI, 1.18-1.92) vs never users. No significant association was found between age at initiation and age at diagnosis (estimated regression coefficient, −0.09 [95% CI, −1.11 to 0.94] for age at initiation of ≥30 years and −0.02 [95% CI, −1.27 to 1.22] for <30 years vs never use).<p> <p><i>Conclusion and Relevance</i> - The findings provide supporting evidence that there is a dose-response association between indoor tanning and SCC risk among women. The association between cumulative exposure to indoor tanning and SCC risk was the same regardless of duration of use and age at initiation. These results support development of policies that regulate indoor tanning.en_US
dc.descriptionFinal version with altered title.en_US
dc.identifier.citationLergenmuller S, Ghiasvand R, Robsahm R, Green AC, Lund e, Rueegg CS, Veierød MB. Association of lifetime indoor tanning and subsequent risk of cutaneous squamous cell carcinoma. JAMA dermatology. 2019:1-8en_US
dc.identifier.cristinIDFRIDAID 1743448
dc.identifier.doi10.1001/jamadermatol.2019.2681
dc.identifier.issn2168-6068
dc.identifier.issn2168-6084
dc.identifier.urihttps://hdl.handle.net/10037/17300
dc.language.isoengen_US
dc.publisherAmerican Medical Associationen_US
dc.relation.journalJAMA dermatology
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 American Medical Association. All rights reserved.en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleAssociation of lifetime indoor tanning and subsequent risk of cutaneous squamous cell carcinomaen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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