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dc.contributor.authorKollerud, Ruby Del Risco
dc.contributor.authorRuud, Ellen
dc.contributor.authorHaugnes, Hege Sagstuen
dc.contributor.authorCannon-Albright, Lisa A.
dc.contributor.authorThoresen, Magne
dc.contributor.authorNafstad, Per
dc.contributor.authorVlatkovic, Ljiljana
dc.contributor.authorBlaasaas, Karl Gerhard
dc.contributor.authorNæss, Øyvind
dc.contributor.authorClaussen, Bjørgulf
dc.date.accessioned2020-02-12T11:54:13Z
dc.date.available2020-02-12T11:54:13Z
dc.date.issued2019-04-10
dc.description.abstract<i>Background</i> - The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.<p><p> <i>Methods</i> - This is a prospective cohort study including 1,974,287 males born 1951–2015, of whom 2686 were diagnosed with TC before the age of 30.<p><p> <i>Results</i> - A history of TC in male relatives was significantly associated with a diagnosis of TC among children and young adults, including brothers (6.3-fold), sons (4.7-fold), fathers (4.4-fold), paternal uncles (2.0-fold) and maternal uncles (1.9-fold). Individuals with a father diagnosed with a carcinoma or sarcoma showed an elevated risk (1.1-fold and 1.8-fold, respectively). A family history of mesothelioma was positively associated with a risk of TC [(father (2.8-fold), mother (4.6-fold) and maternal uncles and aunt (4.4-fold)]. Elevated risks were also observed when siblings were diagnosed with malignant melanoma (1.4-fold). The risk of TC was also increased when fathers (11.1-fold), paternal (4.9-fold) and maternal uncles and aunts (4.6-fold) were diagnosed with malignant neuroepithelial-tumours.<p><p> <i>Conclusion</i> - We found an increased risk of TC among children and young adults with a family history of TC, carcinoma, mesothelioma, sarcoma, malignant melanoma and malignant neuroepithelial tumours. Hereditary cancer syndromes might underlie some of the associations reported in this study.en_US
dc.descriptionPublished version available at <a href=https://doi.org/10.1038/s41416-019-0445-2>https://doi.org/10.1038/s41416-019-0445-2</a>en_US
dc.identifier.citationKollerud RdRd, Ruud E, Haugnes h, Cannon-Albright LA, Thoresen M, Nafstad P, Vlatkovic L, Blaasaas KG, Næss Ø, Claussen B. Family history of cancer and risk of paediatric and young adult’s testicular cancer: A Norwegian cohort study. British Journal of Cancer. 2019;120:1007-1014en_US
dc.identifier.cristinIDFRIDAID 1691780
dc.identifier.doi10.1038/s41416-019-0445-2
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/17374
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBritish Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/Norway/?/?/en_US
dc.relation.urihttps://rdcu.be/bvGLC
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleFamily history of cancer and risk of paediatric and young adult’s testicular cancer: A Norwegian cohort studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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