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dc.contributor.authorKey, Timothy J.
dc.contributor.authorAppleby, Paul N.
dc.contributor.authorBradbury, Kathryn E.
dc.contributor.authorSweeting, Michael
dc.contributor.authorWood, Angela
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorKühn, Tilman
dc.contributor.authorSteur, Marinka
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorWennberg, Maria
dc.contributor.authorWürtz, Anne Mette Lund
dc.contributor.authorAgudo, Antonio
dc.contributor.authorAndersson, Jonas
dc.contributor.authorArriola, Larraitz
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBoer, Jolanda M.A.
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorCross, Amanda J.
dc.contributor.authorEricson, Ulrika
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorFerrari, Pietro
dc.contributor.authorGunter, Marc
dc.contributor.authorHuerta, José María
dc.contributor.authorKatzke, Verena
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorMoreno-Iribas, Conchi
dc.contributor.authorNaska, Androniki
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorOlsen, Anja
dc.contributor.authorOvervad, Kim
dc.contributor.authorPalli, Domenico
dc.contributor.authorPanico, Salvatore
dc.contributor.authorMolina-Portillo, Elena
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorSkeie, Guri
dc.contributor.authorSluijs, Ivonne
dc.contributor.authorSonestedt, Emily
dc.contributor.authorStepien, Magdalena
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTumino, Rosario
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorVerschuren, W.M. Monique
dc.contributor.authordi Angelantonio, Emanuele
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorForouhi, Nita
dc.contributor.authorWareham, Nick
dc.contributor.authorButterworth, Adam
dc.contributor.authorRiboli, Elio
dc.contributor.authorDanesh, John
dc.date.accessioned2020-02-12T13:28:49Z
dc.date.available2020-02-12T13:28:49Z
dc.date.issued2019-04-22
dc.description.abstract<i>Background</i> - There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition).<P><P> <i>Methods</i> - In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validated questionnaires and calibrated with 24-hour recalls. Lipids and blood pressure were measured in a subsample. During a mean of 12.6 years of follow-up, 7198 participants had a myocardial infarction or died of IHD. The relationships of animal foods with risk were examined with Cox regression with adjustment for other animal foods and relevant covariates.<p><p> <i>Results</i> - The hazard ratio (HR) for IHD was 1.19 (95% CI, 1.06–1.33) for a 100-g/d increment in intake of red and processed meat, and this remained significant after exclusion of the first 4 years of follow-up (HR, 1.25 [95% CI, 1.09–1.42]). Risk was inversely associated with intakes of yogurt (HR, 0.93 [95% CI, 0.89–0.98] per 100-g/d increment), cheese (HR, 0.92 [95% CI, 0.86–0.98] per 30-g/d increment), and eggs (HR, 0.93 [95% CI, 0.88–0.99] per 20-g/d increment); the associations with yogurt and eggs were attenuated and nonsignificant after exclusion of the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish, or milk. In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese, or eggs was associated with ≈20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non–high-density lipoprotein cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non–high-density lipoprotein cholesterol.<p><p> <i>Conclusions</i> - Risk for IHD was positively associated with consumption of red and processed meat and inversely associated with consumption of yogurt, cheese, and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It is not clear whether the associations with red and processed meat and cheese reflect causality, but they were consistent with the associations of these foods with plasma non–high-density lipoprotein cholesterol and for red and processed meat with systolic blood pressure, which could mediate such effects.en_US
dc.identifier.citationKey TJ, Appleby PN, Bradbury KE, Sweeting M, Wood A, Johansson I, Kühn T, Steur, Weiderpass E, Wennberg M, Würtz AML, Agudo A, Andersson, Arriola L, Boeing H, Boer JM, Bonnet F, Boutron-Ruault M, Cross AJ, Ericson U, Fagherazzi G, Ferrari P, Gunter M, Huerta JM, Katzke V, Khaw K, Krogh V, La Vecchia C, Matullo G, Moreno-Iribas C, Naska A, Nilsson LM, Olsen A, Overvad K, Palli D, Panico S, Molina-Portillo E, Quirós JR, Skeie G, Sluijs I, Sonestedt E, Stepien M, Tjønneland A, Trichopoulou A, Tumino R, Tzoulaki I, van der Schouw YT, Verschuren WM, di Angelantonio E, Langenberg C, Forouhi N, Wareham N, Butterworth A, Riboli E, Danesh J. Consumption of meat, fish, dairy products, and eggs and risk of ischemic heart disease: A prospective study of 7198 incident cases among 409 885 participants in the Pan-European EPIC Cohort. Circulation. 2019;139(25):2835-2845en_US
dc.identifier.cristinIDFRIDAID 1747599
dc.identifier.doi10.1161/CIRCULATIONAHA.118.038813
dc.identifier.issn0009-7322
dc.identifier.issn1524-4539
dc.identifier.urihttps://hdl.handle.net/10037/17379
dc.language.isoengen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.journalCirculation
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/268834/EU/Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart/EPICHEART/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/279233/EU/EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations/EPIC-CVD/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleConsumption of meat, fish, dairy products, and eggs and risk of ischemic heart disease: A prospective study of 7198 incident cases among 409 885 participants in the Pan-European EPIC Cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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