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dc.contributor.authorAviles Solis, Juan Carlos
dc.contributor.authorJacome, Cristina
dc.contributor.authorDavidsen, Anne Herefoss
dc.contributor.authorEinarsen, R
dc.contributor.authorVanbelle, Sophie
dc.contributor.authorPasterkamp, Hans
dc.contributor.authorMelbye, Hasse
dc.date.accessioned2020-02-25T08:54:58Z
dc.date.available2020-02-25T08:54:58Z
dc.date.issued2019-09-11
dc.description.abstract<i>Background</i> - Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status and lung function.<p> <p><i>Methods</i> - We recorded lung sounds in 4033 individuals 40 years or older and collected information on self-reported disease. Pulse oximetry and spirometry were carried out. We estimated age-standardized prevalence of wheezes and crackles and associations between wheezes and crackles and variables of interest were analyzed with univariable and multivariable logistic regressions.<p> <p><i>Results</i> - Twenty-eight percent of individuals had wheezes or crackles. The age-standardized prevalence of wheezes was 18.6% in women and 15.3% in men, and of crackles, 10.8 and 9.4%, respectively. Wheezes were mostly found during expiration and crackles during inspiration. Significant predictors of expiratory wheezes in multivariable analyses were age (10 years increase - OR 1.18, 95%CI 1.09–1.30), female gender (1.45, 1.2–1.8), self-reported asthma (1.36, 1.00–1.83), and current smoking (1.70, 1.28–2.23). The most important predictors of inspiratory crackles were age (1.76, 1.57–1.99), current smoking, (1.94, 1.40–2.69), mMRC ≥2 (1.79, 1.18–2.65), SpO2 (0.88, 0.81–0.96), and FEV1 Z-score (0.86, 0.77–0.95).<p> <p><i>Conclusions</i> - Nearly over a quarter of adults present adventitious lung sounds on auscultation. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with self-reported disease, current smoking and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings.en_US
dc.identifier.citationAviles Solis, Jacome C, Davidsen AH, Einarsen, Vanbelle S, Pasterkamp H, Melbye H. Prevalence and clinical associations of wheezes and crackles in the general population: The Troms? study. BMC Pulmonary Medicine. 2019;19(1)en_US
dc.identifier.cristinIDFRIDAID 1739858
dc.identifier.doi10.1186/s12890-019-0928-1
dc.identifier.issn1471-2466
dc.identifier.urihttps://hdl.handle.net/10037/17481
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofAviles Solis, J.C. (2020). Identification and prevalence of adventitious lung sounds in a general adult population. (Doctoral thesis). <a href=https://hdl.handle.net/10037/17825>https://hdl.handle.net/10037/17825. </a>
dc.relation.journalBMC Pulmonary Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titlePrevalence and clinical associations of wheezes and crackles in the general population: The Tromsø studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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