Show simple item record

dc.contributor.authorNeerland, Eirik D.
dc.contributor.authorBytingsvik, Jenny
dc.contributor.authorNikiforov, Vladimir
dc.contributor.authorEvenset, Anita
dc.contributor.authorKrøkje, Åse
dc.date.accessioned2020-03-13T12:49:42Z
dc.date.available2020-03-13T12:49:42Z
dc.date.issued2019-07-25
dc.description.abstractHigh levels of organochlorine contaminants (OCs) have been found in arctic char (<i>Salvelinus alpinus</i>) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic effect of environmental organochlorine contaminant exposure in arctic char from Ellasjøen compared with arctic char from the low‐contaminated Lake Laksvatn nearby. Blood was analyzed using agarose gel electrophoresis and image data analysis to quantify the fraction of total DNA that migrated into the gel (DNA‐FTM) as a relative measure of DNA double‐strand breaks (DSBs). Analysis by GC‐MS of muscle samples showed an average 43 times higher concentration of ΣOCs in arctic char from Ellasjøen (<i>n</i> = 18) compared with Laksvatn char (<i>n</i> = 21). Char from Lake Ellasjøen had a much higher frequency of DSBs, as measured by DNA‐FTM, than char from Lake Laksvatn. Principal component analysis and multiple linear regressions show that there was a significant positive relationship between DSBs and levels of organochlorine contaminants in the char. In addition, DSBs were less frequent in reproductively mature char than in immature char. The results suggest that organochlorine contaminants are genotoxic to arctic char.en_US
dc.identifier.citationNeerland, Bytingsvik J, Nikiforov V, Evenset A, Krøkje Å. DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic. Environmental Toxicology and Chemistry. 2019;38(11):2405-2413en_US
dc.identifier.cristinIDFRIDAID 1735983
dc.identifier.doi10.1002/etc.4546
dc.identifier.issn0730-7268
dc.identifier.issn1552-8618
dc.identifier.urihttps://hdl.handle.net/10037/17735
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalEnvironmental Toxicology and Chemistry
dc.relation.projectIDNorges forskningsråd: 221371en_US
dc.relation.projectIDFramsenteret: Flagship "Hazardous substances"en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/221371/Norway/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400en_US
dc.titleDNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arcticen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record