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dc.contributor.authorTepekule, Burcu
dc.contributor.authorAbel zur Wiesch, Pia
dc.contributor.authorKouyos, Roger D.
dc.contributor.authorBonhoeffer, Sebastian
dc.date.accessioned2020-03-26T08:38:36Z
dc.date.available2020-03-26T08:38:36Z
dc.date.issued2019-10-30
dc.description.abstractTo understand how antibiotic use affects the risk of a resistant infection, we present a computational model of the population dynamics of gut microbiota including antibiotic resistance-conferring plasmids. We then describe how this model is parameterized based on published microbiota data. Finally, we investigate how treatment history affects the prevalence of resistance among opportunistic enterobacterial pathogens. We simulate treatment histories and identify which properties of prior antibiotic exposure are most influential in determining the prevalence of resistance. We find that resistance prevalence can be predicted by 3 properties, namely the total days of drug exposure, the duration of the drug-free period after last treatment, and the center of mass of the treatment pattern. Overall this work provides a framework for capturing the role of the microbiome in the selection of antibiotic resistance and highlights the role of treatment history for the prevalence of resistance.en_US
dc.identifier.citationTepekule, Abel zur Wiesch P, Kouyos RD, Bonhoeffer S. Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(46):23106-23116en_US
dc.identifier.cristinIDFRIDAID 1761539
dc.identifier.doi10.1073/pnas.1912188116
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/10037/17858
dc.language.isoengen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dc.relation.projectIDNorges forskningsråd: 187615en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/EMBLNODE/187615/Norway/Norsk senter for molekylærmedisin (NCMM) - Centre for Molecular Medicine Norway - Nordic EMBL Partnership//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.titleQuantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiotaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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